Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 6/20 | 0.58 |
| ▸ | KDR | P35968 | 3/20 | 0.58 |
| ▸ | EGFR | P00533 | 3/20 | 0.58 |
| ▸ | EPHX2 | P34913 | 8/20 | 0.52 |
| ▸ | RAF1 | P04049 | 2/20 | 0.51 |
| ▸ | RET | P07949 | 2/20 | 0.48 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.48 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9902789 | 0.89 | EPHX2 (0.54) | BRAFKDREGFREPHX2RAF1 | |
| SCHEMBL3763732 | 0.83 | NTRK1 (0.43) | BRAFKDREGFRRAF1RET | |
| SCHEMBL3763784 | 0.81 | KDR (0.47) | BRAFKDREGFRRAF1RET | |
| SCHEMBL9903598 | 0.80 | BRAF (0.52) | BRAFKDREGFRRAF1MAPK14 | |
| SCHEMBL3832628 | 0.79 | EPHX2 (0.53) | BRAFKDREGFREPHX2RAF1 | |
| SCHEMBL9946550 | 0.78 | NTRK1 (0.39) | BRAFKDREGFRRAF1RET | |
| SCHEMBL3767827 | 0.78 | CDK8 (0.50) | KDRRET | |
| SCHEMBL3762266 | 0.77 | KIT (0.62) | BRAFKDRRAF1RET | |
| SCHEMBL12694305 | 0.74 | KDR (1.00) | BRAFKDREGFRRETMAPK14 | |
| SCHEMBL3762938 | 0.72 | RET (0.60) | BRAFKDRRETMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1809629-B1 | N,N'-diphenyl urea derivatives suitable for the treatment of tumours, eye diseases, inflammation and diseases of the immune system | MERCK PATENT GMBH (DE) | 2012-06-13 | — | — | EP | claimed |