Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 7/20 | 0.52 |
| ▸ | RAF1 | P04049 | 3/20 | 0.52 |
| ▸ | ARAF | P10398 | 3/20 | 0.52 |
| ▸ | KDR | P35968 | 9/20 | 0.52 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.52 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.49 |
| ▸ | ABL1 | P00519 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 3/20 | 0.43 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.43 |
| ▸ | F2 | P00734 | 1/20 | 0.41 |
| ▸ | F10 | P00742 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.40 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.40 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | CDK1 | P06493 | 1/20 | 0.40 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.40 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.40 |
| ▸ | FLT1 | P17948 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3763784 | 0.85 | KDR (0.47) | BRAFRAF1KDREGFRNTRK1 | |
| SCHEMBL3767003 | 0.82 | BRAF (0.42) | BRAFRAF1ARAFKDRFGFR1 | |
| SCHEMBL3763732 | 0.80 | NTRK1 (0.43) | BRAFRAF1KDRMAPK14EGFR | |
| SCHEMBL9903084 | 0.80 | BRAF (0.58) | BRAFRAF1KDRMAPK14EGFR | |
| SCHEMBL3767827 | 0.79 | CDK8 (0.50) | KDRABL1NTRK1NTRK3NTRK2 | |
| SCHEMBL3762266 | 0.79 | KIT (0.62) | BRAFRAF1KDRNTRK1NTRK3 | |
| SCHEMBL3831499 | 0.78 | KDR (0.51) | BRAFRAF1ARAFKDRFGFR1 | |
| SCHEMBL9946550 | 0.76 | NTRK1 (0.39) | BRAFRAF1KDREGFRERBB2 | |
| SCHEMBL4933246 | 0.75 | KDR (0.63) | BRAFRAF1ARAFKDRFGFR1 | |
| SCHEMBL3768545 | 0.74 | BRAF (0.51) | BRAFRAF1KDRMAPK14NTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1809629-B1 | N,N'-diphenyl urea derivatives suitable for the treatment of tumours, eye diseases, inflammation and diseases of the immune system | MERCK PATENT GMBH (DE) | 2012-06-13 | — | — | EP | claimed |