Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | PTGS1 | P23219 | 6/20 | 0.45 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.44 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.42 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.39 |
| ▸ | LOX | P28300 | 1/20 | 0.38 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 2/20 | 0.37 |
| ▸ | CDK1 | P06493 | 1/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | PTGES | O14684 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9902465 | 0.98 | SMN1; SMN2 (0.55) | SMN1; SMN2LMNAPTGS1TLR8PDGFRB | |
| SCHEMBL9903034 | 0.95 | LMNA (0.55) | SMN1; SMN2LMNAPTGS1TLR8PDGFRB | |
| SCHEMBL9905300 | 0.91 | LMNA (0.58) | SMN1; SMN2LMNAPTGS1TLR8PDGFRB | |
| SCHEMBL28211078 | 0.80 | LOX (0.41) | SMN1; SMN2LMNAPTGS1PDGFRBPDGFRA | |
| SCHEMBL1067726 | 0.70 | SMN1; SMN2 (1.00) | SMN1; SMN2LMNAPTGS2ALDH1A1CYP1A2 | |
| SCHEMBL9309427 | 0.69 | PDGFRB (0.41) | PTGS1PDGFRBPDGFRALOXLOXL2 | |
| SCHEMBL31403712 | 0.67 | LOX (0.40) | PTGS1PDGFRBPDGFRALOXLOXL2 | |
| SCHEMBL19890923 | 0.67 | PDGFRB (0.43) | SMN1; SMN2LMNAPDGFRBPDGFRALOX | |
| SCHEMBL24156612 | 0.66 | PTGS1 (0.38) | PTGS1PDGFRBPDGFRACYP19A1 | |
| SCHEMBL30252998 | 0.66 | PTGS1 (0.38) | PTGS1PDGFRBPDGFRACYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2463277-B1 | METHOD FOR PRODUCING 4,6-DIALKOXY-2-CYANOMETHYLPYRIMIDINE AND SYNTHETIC INTERMEDIATE THEREOF | KUMIAI CHEMICAL INDUSTRY CO (JP) | 2017-11-08 | — | — | EP | disclosed |
| CN-105130908-A | Method for producing 4,6-dialkoxy-2-cyanomethylpyrimidine and synthetic intermediate thereof | IHARA CHEMICAL IND CO | 2015-12-09 | — | — | CN | disclosed |
| CN-102548972-B | Preparation method of 4, 6-dialkoxy-2-cyanomethylpyrimidine and synthetic intermediate thereof | IHARA CHEMICAL INDUSTRY CO.,LTD. (JP) | 2015-08-19 | — | — | CN | disclosed |
| US-8748605-B2 | Method for producing 4,6-dialkoxy-2-cyanomethylpyrimidine and synthetic intermediate thereof | IHARA CHEMICAL INDUSTRY CO., LTD. (JP) | 2014-06-10 | — | — | US | disclosed |
| US-20120190851-A1 | METHOD FOR PRODUCING 4,6-DIALKOXY-2-CYANOMETHYLPYRIMIDINE AND SYNTHETIC INTERMEDIATE THEREOF | IHARA CHEMICAL INDUSTRY CO., LTD. (JP) | 2012-07-26 | — | — | US | disclosed |
| EP-2463277-A1 | METHOD FOR PRODUCING 4,6-DIALKOXY-2-CYANOMETHYLPYRIMIDINE AND SYNTHETIC INTERMEDIATE THEREOF | Ihara Chemical Industry Co., Ltd. (JP) | 2012-06-13 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120190851-A1 | METHOD FOR PRODUCING 4,6-DIALKOXY-2-CYANOMETHYLPYRIMIDINE AND SYNTHETIC INTERMEDIATE THEREOF | DPYD, TYMP, DTYMK | SMN1; SMN2 2788/4885LMNA 3856/4885PTGS1 1571/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.