Sugi Predict

Sugi Predict / Compounds / SCHEMBL1067726

SCHEMBL1067726

SCHEMBL1067726

COc1cc(OC)nc(S(C)(=O)=O)n1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ SMN1; SMN2 Q16637 4/20 1.00
▸ LMNA P02545 4/20 1.00
▸ CYP1A2 P05177 1/20 0.42
▸ KDM4E B2RXH2 3/20 0.41
▸ ALDH1A1 P00352 2/20 0.41
▸ HPGD P15428 3/20 0.41
▸ NPSR1 Q6W5P4 3/20 0.41
▸ TP53 P04637 3/20 0.41
▸ KMT2A Q03164 2/20 0.41
▸ USP2 O75604 1/20 0.41
▸ L3MBTL1 Q9Y468 2/20 0.39
▸ HTT P42858 2/20 0.39
▸ MITF O75030 1/20 0.39
▸ STAT3 P40763 1/20 0.39
▸ HSD17B10 Q99714 1/20 0.39
▸ TDP1 Q9NUW8 1/20 0.37
▸ GLA P06280 1/20 0.36
▸ MAPT P10636 1/20 0.36
▸ TSHR P16473 1/20 0.36
▸ GAA P10253 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8666206 0.88 SMN1; SMN2 (0.78) SMN1; SMN2LMNACYP1A2KDM4EALDH1A1
SCHEMBL5360302 0.88 LMNA (0.78) SMN1; SMN2LMNACYP1A2KDM4EALDH1A1
SCHEMBL6561352 0.88 SMN1; SMN2 (0.78) SMN1; SMN2LMNACYP1A2KDM4EALDH1A1
SCHEMBL6806477 0.86 LMNA (0.75) SMN1; SMN2LMNACYP1A2KDM4EALDH1A1
SCHEMBL9432915 0.86 LMNA (0.73) SMN1; SMN2LMNACYP1A2KDM4EALDH1A1
SCHEMBL4433293 0.85 LMNA (0.74) SMN1; SMN2LMNACYP1A2KDM4EALDH1A1
SCHEMBL9432383 0.83 SMN1; SMN2 (0.70) SMN1; SMN2LMNACYP1A2KDM4EALDH1A1
SCHEMBL9432808 0.83 LMNA (0.70) SMN1; SMN2LMNACYP1A2KDM4EALDH1A1
SCHEMBL15998734 0.82 SMN1; SMN2 (0.68) SMN1; SMN2LMNACYP1A2KDM4EALDH1A1
SCHEMBL8446796 0.82 LMNA (0.68) SMN1; SMN2LMNAKDM4EALDH1A1HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 623 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119100995-A Acetohydroxyacid synthase inhibitors, process for their preparation and their use as herbicides 浙江大学 2024-12-10 — — CN claimed
CN-119100996-A Pyrimidine-biaryl compound, preparation method and application as herbicide 浙江大学 2024-12-10 — — CN claimed
CN-114933568-B Preparation method of 4, 6-dimethyl-2-methylsulfonyl pyrimidine 抚州润泰药业有限公司 2024-11-26 — — CN claimed
CN-118480008-A Green synthesis method of herbicide pyriminobac-methyl in paddy field 常州大学 2024-08-13 — — CN claimed
CN-118373806-A Pyrimidine benzamide derivative and preparation method and application thereof 南京农业大学 2024-07-23 — — CN claimed
CN-118307483-A Preparation method of 2-methylsulfonyl-4, 6-dimethoxy pyrimidine 新沂大江化工有限公司 2024-07-09 — — CN claimed
CN-113651760-B Pyrimidine selenobenzoic acid derivative, preparation method thereof and application of pyrimidine selenobenzoic acid derivative as herbicide 常州大学 2023-07-25 — — CN claimed
CN-218167252-U Cooling structure for preparing 4, 6-dimethoxy-2-methylsulfonylpyrimidine 新沂大江化工有限公司 2022-12-30 — — CN claimed
CN-114933568-A Preparation method of 4, 6-dimethyl-2-methylsulfonyl pyrimidine 抚州润泰药业有限公司 2022-08-23 — — CN claimed
CN-113651760-A Pyrimidine selenium benzoic acid derivative, preparation method thereof and application of pyrimidine selenium benzoic acid derivative as herbicide 常州大学 2021-11-16 — — CN claimed
US-6693194-B2 BY REACTING 4,6-DICHLORO-2-(METHYLTHIO)PYRIMIDINE IN AN INERT ORGANIC SOLVENT WITH AN ALKALI METAL METHOXIDE, TRANSFERRING TO AN AQUEOUS ACID MEDIUM AND OXIDATION; USING THE PRODUCT TO PREPARE 7-((4,6- SYNGENTA CROP PROTECTION, INC. 2004-02-17 — — US claimed
CN-1443175-A Process for the preparation of 4, 6-dimethoxy-2- (methylsulfonyl) -1, 3-pyrimidine SYNGENTA PARITCIPATIONS AG (CH) 2003-09-17 — — CN claimed
US-20030135047-A1 Process for the preparation of 4,6-dimethoxy-2-(methylsulfonyl)-1,3-pyrimidine SYNGENTA CORP PROTECTION, INC. 2003-07-17 — — US claimed
EP-1301491-A1 PROCESS FOR THE PREPARATION OF 4,6-DIMETHOXY-2-(METHYLSULFONYL)-1,3-PYRIMIDINE Syngenta Participations AG (CH) 2003-04-16 — — EP claimed
US-20020095037-A1 Method of producing thiobarbituric acid derivatives SYNGENTA CROP PROTECTION, INC. 2002-07-18 — — US claimed
CN-1339029-A Method of producing thiobarbituric acid derivatives SINGENTA PARTICIPATION AG (CH) 2002-03-06 — — CN claimed
WO-2002008207-A1 PROCESS FOR THE PREPARATION OF 4,6-DIMETHOXY-2-(METHYLSULFONYL)-1,3-PYRIMIDINE SYNGENTA PARTICIPATIONS AG (CH) 2002-01-31 — — WO claimed
EP-1165524-A2 METHOD OF PRODUCING THIOBARBITURIC ACID DERIVATIVES Syngenta Participations AG (CH) 2002-01-02 — — EP claimed
WO-2000046213-A2 METHOD OF PRODUCING THIOBARBITURIC ACID DERIVATIVES SYNGENTA PARTICIPATIONS AG (CH) 2000-08-10 — — WO claimed
WO-2000046212-A1 METHOD OF PRODUCING SUBSTITUTED PYRIMIDINE DERIVATIVES SYNGENTA PARTICIPATIONS AG (CH) 2000-08-10 — — WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020095037-A1 Method of producing thiobarbituric acid derivatives BHMT2, MGMT, MRM1 SMN1; SMN2 2744/4885LMNA 4402/4885CYP1A2 358/4885
US-20030135047-A1 Process for the preparation of 4,6-dimethoxy-2-(methylsulfonyl)-1,3-pyrimidine TPMT, DHODH, DPYD SMN1; SMN2 897/4885LMNA 4325/4885CYP1A2 189/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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