Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 3/20 | 0.56 |
| ▸ | PPARG | P37231 | 1/20 | 0.56 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.56 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.56 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.56 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.56 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.56 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.56 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.50 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.49 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.48 |
| ▸ | DPEP1 | P16444 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.44 |
| ▸ | NQO2 | P16083 | 1/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.42 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9903274 | 1.00 | EPHX2 (0.56) | EPHX2PPARGPSEN1PSEN2APH1B | |
| SCHEMBL16969112 | 0.87 | AKR1C3 (0.47) | EPHX2PPARGPSEN1PSEN2APH1B | |
| SCHEMBL5173409 | 0.86 | TBXAS1 (0.58) | EPHX2PPARGAKR1C3TBXAS1 | |
| SCHEMBL3995073 | 0.85 | TRPV1 (0.50) | EPHX2PPARGPSEN1PSEN2APH1B | |
| SCHEMBL3995067 | 0.85 | TRPV1 (0.50) | EPHX2PPARGPSEN1PSEN2APH1B | |
| SCHEMBL8865367 | 0.83 | PTPN1 (0.50) | EPHX2PPARGPSEN1PSEN2APH1B | |
| SCHEMBL8865356 | 0.83 | PTPN1 (0.50) | EPHX2PPARGPSEN1PSEN2APH1B | |
| SCHEMBL5094454 | 0.81 | EPHX2 (0.55) | EPHX2PPARGPSEN1PSEN2APH1B | |
| SCHEMBL5094449 | 0.81 | EPHX2 (0.55) | EPHX2PPARGPSEN1PSEN2APH1B | |
| SCHEMBL4662669 | 0.81 | MEN1 (0.51) | EPHX2PPARGAKR1C3TBXAS1DPEP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1981884-B1 | THIAZOLE COMPOUNDS AS PROTEIN KINASE B (PKB) INHIBITORS | AMGEN INC (US) | 2012-06-13 | — | — | EP | disclosed |