Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 11/20 | 0.62 |
| ▸ | GRM1 | Q13255 | 9/20 | 0.44 |
| ▸ | KIT | P10721 | 7/20 | 0.42 |
| ▸ | DDR1 | Q08345 | 7/20 | 0.42 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.39 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9903855 | 0.81 | GRM5 (0.50) | GRM5 | |
| SCHEMBL19989696 | 0.80 | GRM5 (0.69) | GRM5GRM1PDK4 | |
| SCHEMBL3348848 | 0.80 | GRM5 (0.66) | GRM5GRM1PDK4 | |
| SCHEMBL14995149 | 0.79 | GRM5 (0.70) | GRM5GRM1PDK4 | |
| SCHEMBL4047546 | 0.78 | GRM5 (0.60) | GRM5GRM1PDK4 | |
| SCHEMBL941018 | 0.75 | GRM5 (0.61) | GRM5GRM1PDK4 | |
| SCHEMBL3348910 | 0.74 | GRM5 (0.66) | GRM5GRM1PDK4 | |
| SCHEMBL8142754 | 0.73 | GRM5 (0.59) | GRM5GRM1PDK4 | |
| SCHEMBL2893138 | 0.73 | GRM5 (0.63) | GRM5GRM1PDK4 | |
| SCHEMBL22027708 | 0.72 | RET (0.49) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120178742-A1 | METABOTROPIC GLUTAMATE RECEPTOR MODULATORS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2012-07-12 | — | — | US | claimed |
| EP-2462142-A1 | METABOTROPIC GLUTAMATE RECEPTOR MODULATORS | Merz Pharma GmbH & Co. KGaA (DE) | 2012-06-13 | — | — | EP | claimed |
| US-20120178742-A1 | METABOTROPIC GLUTAMATE RECEPTOR MODULATORS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2012-07-12 | — | — | US | disclosed |
| EP-2462142-A1 | METABOTROPIC GLUTAMATE RECEPTOR MODULATORS | Merz Pharma GmbH & Co. KGaA (DE) | 2012-06-13 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120178742-A1 | METABOTROPIC GLUTAMATE RECEPTOR MODULATORS | GRM5, GRIK5, GRM1 | GRM5 1/4885GRM1 3/4885KIT 4512/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.