Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 13/20 | 0.66 |
| ▸ | GRM1 | Q13255 | 9/20 | 0.41 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.40 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.39 |
| ▸ | OGA | O60502 | 1/20 | 0.38 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.38 |
| ▸ | NAMPT | P43490 | 1/20 | 0.38 |
| ▸ | JAK1 | P23458 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3345905 | 0.82 | GRM5 (0.68) | GRM5OGA | |
| SCHEMBL3348318 | 0.80 | GRM5 (0.43) | GRM5PCSK9OGA | |
| SCHEMBL16553430 | 0.80 | GRM1 (0.54) | GRM5GRM1PDK4TNK2NAMPT | |
| SCHEMBL9903364 | 0.80 | GRM5 (0.62) | GRM5GRM1PDK4 | |
| SCHEMBL3348323 | 0.79 | GRM5 (0.42) | GRM5PCSK9OGANAMPTJAK1 | |
| SCHEMBL19989696 | 0.77 | GRM5 (0.69) | GRM5GRM1PDK4NAMPT | |
| SCHEMBL14995149 | 0.75 | GRM5 (0.70) | GRM5GRM1PDK4NAMPT | |
| SCHEMBL3348910 | 0.75 | GRM5 (0.66) | GRM5GRM1PDK4NAMPTJAK1 | |
| SCHEMBL2893138 | 0.73 | GRM5 (0.63) | GRM5GRM1PDK4NAMPTJAK1 | |
| SCHEMBL8139008 | 0.72 | GRM5 (0.62) | GRM5GRM1PDK4NAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010063487-A1 | PYRAZOLOPYRIMIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICINE | MERZ PHARMA GMBH & CO. KGAA (DE) | 2010-06-10 | — | — | WO | claimed |
| WO-2010063487-A1 | PYRAZOLOPYRIMIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICINE | MERZ PHARMA GMBH & CO. KGAA (DE) | 2010-06-10 | — | — | WO | disclosed |