Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 12/20 | 0.66 |
| ▸ | GRM1 | Q13255 | 9/20 | 0.46 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.44 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.42 |
| ▸ | NAMPT | P43490 | 1/20 | 0.41 |
| ▸ | JAK1 | P23458 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5796435 | 0.91 | GRM5 (0.57) | GRM5GRM1PDK4ESR2NAMPT | |
| SCHEMBL2893138 | 0.85 | GRM5 (0.63) | GRM5GRM1PDK4ESR2NAMPT | |
| SCHEMBL2290995 | 0.82 | GRM5 (0.44) | GRM5SMN1; SMN2 | |
| SCHEMBL20001581 | 0.82 | GRM5 (0.60) | GRM5GRM1PDK4ESR2NAMPT | |
| SCHEMBL19989696 | 0.81 | GRM5 (0.69) | GRM5GRM1PDK4ESR2NAMPT | |
| SCHEMBL2891556 | 0.81 | GRM5 (0.58) | GRM5GRM1PDK4ESR2NAMPT | |
| SCHEMBL2893109 | 0.81 | GRM5 (0.58) | GRM5GRM1PDK4ESR2NAMPT | |
| SCHEMBL743098 | 0.81 | GRM5 (0.58) | GRM5GRM1PDK4ESR2NAMPT | |
| SCHEMBL15991177 | 0.81 | GRM5 (0.58) | GRM5GRM1PDK4ESR2NAMPT | |
| SCHEMBL31558715 | 0.80 | GRM5 (0.43) | GRM5NAMPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119816496-A | Aromatic acetylene derivative and preparation method and application thereof | 浙江海正药业股份有限公司 | 2025-04-11 | — | — | CN | disclosed |
| US-20240400555-A1 | Compounds, Compositions and Methods for Attenuation of Mammalian Translation of C-MYC or N-MYC Proteins of the MYC Proto-Oncogene Family of BHLH Transcription Factors | INITIAL THERAPEUTICS, INC. (US) | 2024-12-05 | — | — | US | disclosed |
| WO-2024226875-A2 | COMPOUNDS, COMPOSITIONS AND METHODS FOR ATTENUATION OF MAMMALIAN TRANSLATION OF C-MYC OR N-MYC PROTEINS OF THE MYC PROTO-ONCOGENE FAMILY OF BHLH TRANSCRIPTION FACTORS | INITIAL THERAPEUTICS, INC. (US) | 2024-10-31 | — | — | WO | disclosed |
| WO-2024067812-A1 | AROMATIC ACETYLENE DERIVATIVE, PREPARATION METHOD THEREFOR, AND USE THEREOF | 浙江海正药业股份有限公司 | 2024-04-04 | — | — | WO | disclosed |
| CN-110088087-B | Tetrahydropyridine derivatives and their use as antibacterial agents | 东亚ST株式会社 | 2022-08-09 | — | — | CN | disclosed |
| EP-3519387-B1 | TETRAHYDROPYRIDINE DERIVATIVES AND THEIR USE AS ANTIBACTERIAL AGENTS | DONG A ST CO LTD (KR) | 2021-08-11 | — | — | EP | disclosed |
| EP-3519387-A1 | TETRAHYDROPYRIDINE DERIVATIVES AND THEIR USE AS ANTIBACTERIAL AGENTS | Dong-A ST Co., Ltd. (KR) | 2019-08-07 | — | — | EP | disclosed |
| US-10160724-B2 | Tetrahydropyridine derivatives and their use as antibacterial agents | DONG-A ST CO., LTD. (KR) | 2018-12-25 | — | — | US | disclosed |
| WO-2018062924-A1 | TETRAHYDROPYRIDINE DERIVATIVES AND THEIR USE AS ANTIBACTERIAL AGENTS | DONG-A ST CO., LTD. (KR) | 2018-04-05 | — | — | WO | disclosed |
| WO-2018062924-A1 | TETRAHYDROPYRIDINE DERIVATIVES AND THEIR USE AS ANTIBACTERIAL AGENTS | DONG-A ST CO., LTD. (KR) | 2018-04-05 | — | — | WO | disclosed |
| US-20180086709-A1 | TETRAHYDROPYRIDINE DERIVATIVES AND THEIR USE AS ANTIBACTERIAL AGENTS | DONG-A ST CO., LTD. (KR) | 2018-03-29 | — | — | US | disclosed |
| US-20180086709-A1 | TETRAHYDROPYRIDINE DERIVATIVES AND THEIR USE AS ANTIBACTERIAL AGENTS | DONG-A ST CO., LTD. (KR) | 2018-03-29 | — | — | US | disclosed |
| US-7858800-B2 | Biaryl derivatives | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2010-12-28 | — | — | US | disclosed |
| WO-2010063487-A1 | PYRAZOLOPYRIMIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICINE | MERZ PHARMA GMBH & CO. KGAA (DE) | 2010-06-10 | — | — | WO | disclosed |
| US-20070191389-A1 | Biaryl derivatives | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2007-08-16 | — | — | US | disclosed |
| EP-0775138-B1 | TETRAHYDROPYRIDINYLMETHYL DERIVATIVES OF PYRROLO 2,3-b]PYRIDINE | MERCK SHARP & DOHME (GB) | 2000-02-23 | — | — | EP | disclosed |
| US-5830901-A | Tetrahydropyridinylmethyl derivatives of pyrrolo 2,3-B!pyridine | MERCH SHARP & DOHME LTD | 1998-11-03 | — | — | US | disclosed |
| US-5712285-A | Pyrrolo-pyridine derivatives | MERCK, SHARP & DOHME, LTD. (GB) | 1998-01-27 | — | — | US | disclosed |
| EP-0775138-A1 | TETRAHYDROPYRIDINYLMETHYL DERIVATIVES OF PYRROLO 2,3-b]PYRIDINE | MERCK SHARP & DOHME LTD. (GB) | 1997-05-28 | — | — | EP | disclosed |
| WO-1996005200-A1 | TETRAHYDROPYRIDINYLMETHYL DERIVATIVES OF PYRROLO[2,3-b]PYRIDINE | MERCK SHARP & DOHME LIMITED (GB) | 1996-02-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180086709-A1 | TETRAHYDROPYRIDINE DERIVATIVES AND THEIR USE AS ANTIBACTERIAL AGENTS | GALE, UGDH, PGLS | GRM5 1014/4885GRM1 1124/4885PDK4 1981/4885 |
| US-20240400555-A1 | Compounds, Compositions and Methods for Attenuation of Mammalian Translation of C-MYC or N-MYC Proteins of the MYC Proto-Oncogene Family of BHLH Transcription Factors | MYCBP, MYC, MYCBP2 | GRM5 4240/4885GRM1 3903/4885PDK4 2071/4885 |
| US-20070191389-A1 | Biaryl derivatives | GRM1, GRIN1, GRIN2B | GRM5 26/4885GRM1 1/4885PDK4 638/4885 |
| US-10160724-B2 | Tetrahydropyridine derivatives and their use as antibacterial agents | GALE, UGDH, PGLS | GRM5 1014/4885GRM1 1124/4885PDK4 1981/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.