Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Tryptophan. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | MPO | P05164 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | BLM | P54132 | 1/20 | 0.53 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.53 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.53 |
| ▸ | CTSC | P53634 | 2/20 | 0.49 |
| ▸ | APAF1 | O14727 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.43 |
| ▸ | ERAP2 | Q6P179 | 6/20 | 0.43 |
| ▸ | ERAP1 | Q9NZ08 | 4/20 | 0.43 |
| ▸ | IL1RN | P18510 | 3/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tryptophan SCHEMBL294283 | 0.98 | MEN1 (0.52) | MEN1KMT2AKDM4EMAPTLMNA | |
| Tryptophan SCHEMBL293836 | 0.96 | MEN1 (0.49) | MEN1KMT2AKDM4EMAPTLMNA | |
| Tryptophan SCHEMBL9903583 | 0.95 | MEN1 (0.55) | MEN1KMT2AKDM4EMAPTLMNA | |
| Tryptophan SCHEMBL3442743 | 0.93 | KMT2A (0.61) | MEN1KMT2AKDM4EMAPTLMNA | |
| Tryptophan SCHEMBL3442897 | 0.89 | KDM4E (0.68) | MEN1KMT2AKDM4EMAPTLMNA | |
| D-Tryptophan SCHEMBL2221757 | 0.88 | KMT2A (0.57) | MEN1KMT2AKDM4EMAPTLMNA | |
| Dl-Tryptophan SCHEMBL8937030 | 0.88 | KMT2A (0.70) | MEN1KMT2AKDM4EMAPTLMNA | |
| Tryptophan SCHEMBL3827133 | 0.88 | KMT2A (0.70) | MEN1KMT2AKDM4EMAPTLMNA | |
| Dl-Tryptophan SCHEMBL23924534 | 0.88 | KMT2A (0.70) | MEN1KMT2AKDM4EMAPTLMNA | |
| Dl-Tryptophan SCHEMBL27649388 | 0.87 | MEN1 (0.44) | MEN1KMT2AKDM4EMAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2463378-A1 | Alpha isomaltosylglucosaccharide synthase, process for producing the same and use thereof | KABUSHIKI KAISHA HAYASHIBARA SEIBUTSU KAGAKU KENKYUJO (JP) | 2012-06-13 | — | — | EP | disclosed |