Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Tryptophan. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | MPO | P05164 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | BLM | P54132 | 1/20 | 0.49 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.49 |
| ▸ | CTSC | P53634 | 2/20 | 0.46 |
| ▸ | KISS1R | Q969F8 | 10/20 | 0.44 |
| ▸ | CCKBR | P32239 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.41 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tryptophan SCHEMBL9903592 | 0.96 | MEN1 (0.53) | MEN1KMT2AKDM4ELMNAMPO | |
| Tryptophan SCHEMBL294283 | 0.94 | MEN1 (0.52) | MEN1KMT2AKDM4ELMNAMPO | |
| Tryptophan SCHEMBL9903583 | 0.91 | MEN1 (0.55) | MEN1KMT2AKDM4ELMNAMPO | |
| Tryptophan SCHEMBL4291975 | 0.90 | MEN1 (0.57) | MEN1KMT2AKDM4ELMNAMPO | |
| Tryptophan SCHEMBL3442743 | 0.89 | KMT2A (0.61) | MEN1KMT2AKDM4ELMNAMPO | |
| Dl-Tryptophan SCHEMBL20857030 | 0.86 | KMT2A (0.57) | MEN1KMT2AKDM4ELMNAMPO | |
| Phenylalanine SCHEMBL293835 | 0.86 | MEN1 (0.44) | MEN1KMT2AKDM4ELMNAMPO | |
| Tryptophan SCHEMBL296201 | 0.86 | KMT2A (0.54) | MEN1KMT2AKDM4ELMNAMPO | |
| Tryptophan SCHEMBL5317118 | 0.85 | KMT2A (0.63) | MEN1KMT2AKDM4ELMNAMPO | |
| Tryptophan SCHEMBL3442897 | 0.85 | KDM4E (0.68) | MEN1KMT2AKDM4ELMNAMPO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2463378-B1 | Alpha isomaltosylglucosaccharide synthase, process for producing the same and use thereof | HAYASHIBARA CO (JP) | 2015-12-23 | — | — | EP | disclosed |
| EP-1229112-B1 | ALPHA-ISOMALTOSYLGLUCOSACCHARIDE SYNTHASE, PROCESS FOR PRODUCING THE SAME AND USE THEREOF | HAYASHIBARA BIOCHEM LAB (JP) | 2012-03-14 | — | — | EP | disclosed |
| EP-1445325-B1 | PROCESSES FOR PRODUCING ISOMALTOSE AND ISOMALTITOL AND USE THEREOF | HAYASHIBARA BIOCHEM LAB (JP) | 2010-05-26 | — | — | EP | disclosed |
| EP-1360988-B1 | METHOD FOR DEHYDRATING MOIST ARTICLE USING A CYCLOTETRASACCHARIDE | HAYASHIBARA BIOCHEM LAB (JP) | 2006-10-11 | — | — | EP | disclosed |
| EP-1445325-A1 | PROCESSES FOR PRODUCING ISOMALTOSE AND ISOMALTITOL AND USE THEREOF | Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo (JP) | 2004-08-11 | — | — | EP | disclosed |
| EP-1360988-A1 | DEHYDRATING AGENT AND METHOD FOR DEHYDRATING MOIST ARTICLE USING THE AGENT AND DEHYDRATED ARTICLE OBTAINED BY THE METHOD | Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo (JP) | 2003-11-12 | — | — | EP | disclosed |
| EP-1229112-A1 | ALPHA-ISOMALTOSYLGLUCOSACCHARIDE SYNTHASE, PROCESS FOR PRODUCING THE SAME AND USE THEREOF | Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo (JP) | 2002-08-07 | — | — | EP | disclosed |