Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Tryptophan. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 known ✓ | P0DMS8 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.68 |
| ▸ | MAPT | P10636 | 3/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.68 |
| ▸ | LMNA | P02545 | 2/20 | 0.68 |
| ▸ | TSHR | P16473 | 2/20 | 0.68 |
| ▸ | BLM | P54132 | 2/20 | 0.68 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.68 |
| ▸ | MEN1 | O00255 | 2/20 | 0.68 |
| ▸ | MPO | P05164 | 1/20 | 0.68 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.68 |
| ▸ | APAF1 | O14727 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | RECQL | P46063 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | ECE1 | P42892 | 5/20 | 0.51 |
| ▸ | HTR1A | P08908 | 2/20 | 0.50 |
| ▸ | HTR2A | P28223 | 2/20 | 0.50 |
| ▸ | HTR2C | P28335 | 2/20 | 0.50 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dl-Tryptophan SCHEMBL28171407 | 0.96 | KDM4E (0.74) | KDM4EMAPTKMT2ALMNATSHR | |
| Dl-Tryptophan SCHEMBL28790481 | 0.96 | KDM4E (0.74) | KDM4EMAPTKMT2ALMNATSHR | |
| Tryptophan SCHEMBL6863186 | 0.96 | KDM4E (0.74) | KDM4EMAPTKMT2ALMNATSHR | |
| Tryptophan SCHEMBL7103661 | 0.92 | KDM4E (0.80) | KDM4EMAPTKMT2ALMNATSHR | |
| Dl-Tryptophan SCHEMBL2143522 | 0.91 | KDM4E (0.82) | KDM4EMAPTKMT2ALMNATSHR | |
| Tryptophan SCHEMBL2005670 | 0.91 | KDM4E (0.82) | KDM4EMAPTKMT2ALMNATSHR | |
| Tryptophan SCHEMBL531051 | 0.91 | KDM4E (0.82) | KDM4EMAPTKMT2ALMNATSHR | |
| Tryptophan SCHEMBL8936315 | 0.90 | KDM4E (0.65) | KDM4EMAPTKMT2ALMNATSHR | |
| Tryptophan SCHEMBL9903592 | 0.89 | MEN1 (0.53) | KDM4EMAPTKMT2ALMNATSHR | |
| Tryptophan SCHEMBL7267888 | 0.88 | KDM4E (0.63) | KDM4EMAPTKMT2ALMNATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7811797-B2 | α-isomaltosylglucosaccharide-forming enzyme, process and uses of the same | KABUSHIKI KAISHA HAYASHIBARA SEIBUTSU KAGAKU KENKYUJO (JP) | 2010-10-12 | — | — | US | disclosed |
| US-7718404-B2 | α-isomaltosylglucosaccharide-forming enzyme, process and uses of the same | KABUSHIKI KAISHA HAYASHIBARA SEIBUTSU KAGAKU KENKYUJO (JP) | 2010-05-18 | — | — | US | disclosed |
| US-7592160-B2 | Processes for producing isomaltose and isomaltitol and use thereof | KABUSHIKI KAISHA HAYASHIBARA SEIBUTSU KAGAKU KENKYUJO (JP) | 2009-09-22 | — | — | US | disclosed |
| US-20080032350-A1 | Alpha-isomaltosylglucosaccharide-forming enzyme, process and uses of the same | KABUSHIKI KAISHA HAYASHIBARA SEIBUTSU KAGAKU KENKYUJO (JP) | 2008-02-07 | — | — | US | disclosed |
| US-20080003651-A1 | alpha-isomaltosylglucosaccharide-forming enzyme, process and uses of the same | KABUSHIKI KAISHA HAYASHIBARA SEIBUTSU KAGAKU KENKYUJO (JP) | 2008-01-03 | — | — | US | disclosed |
| US-7241606-B2 | α-Isomaltosylglucosaccharide synthase, process for producing the same and use thereof | KABUSHIKI KAISHA HAYASHIBARA SEIBUTSU KAGAKU KENKYUJO (JP) | 2007-07-10 | — | — | US | disclosed |
| US-7186701-B2 | Dehydrating agent and method for dehydrating moist article using the agent and dehydrated article obtained by the method | KABUSHIKI KAISHA HAYASHIBARA SEIBUTSU KAGAKU KENKYUJO (JP) | 2007-03-06 | — | — | US | disclosed |
| US-20060240531-A1 | Processes for producing isomaltose and isomaltitol and use thereof | KABUSHIKI KAISHA HAYASHIBARA SEIBUTSU KAGAKU KENKYUJO (JP) | 2006-10-26 | — | — | US | disclosed |
| US-20060008791-A1 | Dehydrating agent and method for dehydrating moist article using the agent and dehydrated article obtained by the method | KABUSHIKI KAISHA HAYASHIBARA SEIBUTSU KAGAKU KENKYUJO (JP) | 2006-01-12 | — | — | US | disclosed |