Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.50 |
| ▸ | CDK5 | Q00535 | 4/20 | 0.50 |
| ▸ | CDK5R1 | Q15078 | 4/20 | 0.50 |
| ▸ | PRKD1 | Q15139 | 3/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.50 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | WEE1 | P30291 | 1/20 | 0.38 |
| ▸ | GFER | P55789 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | CALM1 | P0DP23 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9920723 | 1.00 | ALDH1A1 (0.50) | ALDH1A1CDK5CDK5R1PRKD1L3MBTL1 | |
| SCHEMBL17384886 | 0.84 | PRKD1 (0.53) | ALDH1A1CDK5CDK5R1PRKD1L3MBTL1 | |
| SCHEMBL9920805 | 0.80 | PRKD1 (0.48) | ALDH1A1CDK5CDK5R1PRKD1L3MBTL1 | |
| SCHEMBL9904109 | 0.80 | PRKD1 (0.48) | ALDH1A1CDK5CDK5R1PRKD1L3MBTL1 | |
| SCHEMBL9904264 | 0.77 | PRKD1 (0.64) | ALDH1A1CDK5CDK5R1PRKD1L3MBTL1 | |
| SCHEMBL9904140 | 0.77 | PRKD1 (0.45) | ALDH1A1CDK5CDK5R1PRKD1L3MBTL1 | |
| SCHEMBL9920388 | 0.77 | PRKD1 (0.45) | ALDH1A1CDK5CDK5R1PRKD1L3MBTL1 | |
| SCHEMBL19696351 | 0.75 | PRKD1 (0.61) | ALDH1A1CDK5CDK5R1PRKD1L3MBTL1 | |
| SCHEMBL15472031 | 0.75 | PRKD1 (0.61) | ALDH1A1CDK5CDK5R1PRKD1L3MBTL1 | |
| SCHEMBL17384887 | 0.73 | PRKD1 (0.47) | ALDH1A1CDK5CDK5R1PRKD1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9840515-B2 | Protein kinase D inhibitors | University of Pittsburgh—of the Commonwealth System of Higher Education (US) | 2017-12-12 | — | — | US | disclosed |
| US-20140045821-A1 | PROTEIN KINASE D INHIBITORS | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION | 2014-02-13 | — | — | US | disclosed |
| WO-2012078859-A2 | PROTEIN KINASE D INHIBITORS | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2012-06-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140045821-A1 | PROTEIN KINASE D INHIBITORS | PRKCD, PRKD1, PRKD2 | ALDH1A1 4548/4885CDK5 170/4885CDK5R1 223/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.