Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKD1 | Q15139 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.48 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | WEE1 | P30291 | 1/20 | 0.37 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.37 |
| ▸ | CDK1 | P06493 | 1/20 | 0.37 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.37 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9904109 | 1.00 | PRKD1 (0.48) | PRKD1LMNAALDH1A1CDK5CDK5R1 | |
| SCHEMBL17384886 | 0.82 | PRKD1 (0.53) | PRKD1LMNAALDH1A1CDK5CDK5R1 | |
| SCHEMBL9920723 | 0.80 | ALDH1A1 (0.50) | PRKD1LMNAALDH1A1CDK5CDK5R1 | |
| SCHEMBL9904133 | 0.80 | ALDH1A1 (0.50) | PRKD1LMNAALDH1A1CDK5CDK5R1 | |
| SCHEMBL9904264 | 0.75 | PRKD1 (0.64) | PRKD1LMNAALDH1A1CDK5CDK5R1 | |
| SCHEMBL15472031 | 0.73 | PRKD1 (0.61) | PRKD1LMNAALDH1A1CDK5CDK5R1 | |
| SCHEMBL19696351 | 0.73 | PRKD1 (0.61) | PRKD1LMNAALDH1A1CDK5CDK5R1 | |
| SCHEMBL17384887 | 0.71 | PRKD1 (0.47) | PRKD1LMNAALDH1A1CDK5CDK5R1 | |
| SCHEMBL9920687 | 0.70 | PRKD1 (0.84) | PRKD1LMNAALDH1A1CDK5CDK5R1 | |
| SCHEMBL9920388 | 0.69 | PRKD1 (0.45) | PRKD1LMNAALDH1A1CDK5CDK5R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9840515-B2 | Protein kinase D inhibitors | University of Pittsburgh—of the Commonwealth System of Higher Education (US) | 2017-12-12 | — | — | US | disclosed |
| WO-2012078859-A2 | PROTEIN KINASE D INHIBITORS | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2012-06-14 | — | — | WO | disclosed |