Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G7 | Q13093 | 17/20 | 0.49 |
| ▸ | DAO | P14920 | 1/20 | 0.38 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.37 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9107684 | 0.85 | PLA2G7 (0.39) | PLA2G7NR1H2NR1H3 | |
| SCHEMBL9900452 | 0.80 | PLA2G7 (0.55) | PLA2G7DAO | |
| SCHEMBL9904535 | 0.79 | PLA2G7 (0.39) | PLA2G7NR1H2NR1H3 | |
| SCHEMBL9889604 | 0.74 | MCL1 (0.35) | PLA2G7 | |
| SCHEMBL9900826 | 0.74 | CA12 (0.49) | PLA2G7DAO | |
| SCHEMBL9108610 | 0.72 | PLA2G7 (0.37) | PLA2G7 | |
| SCHEMBL9901961 | 0.72 | PLA2G7 (0.57) | PLA2G7 | |
| SCHEMBL9900816 | 0.72 | PLA2G7 (0.47) | PLA2G7 | |
| SCHEMBL9900408 | 0.71 | PLA2G7 (0.56) | PLA2G7 | |
| SCHEMBL9104868 | 0.71 | FLT1 (0.38) | PLA2G7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2649053-A1 | PYRIMIDINONE COMPOUNDS FOR USE IN THE TREATMENT OF DISEASES OR CONDITIONS MEDIATED BY LP - PLA2 | Glaxo Group Limited (GB) | 2013-10-16 | — | — | EP | disclosed |
| WO-2012076435-A1 | PYRIMIDINONE COMPOUNDS FOR USE IN THE TREATMENT OF DISEASES OR CONDITIONS MEDIATED BY LP - PLA2 | GLAXO GROUP LIMITED (GB) | 2012-06-14 | — | — | WO | disclosed |