Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 4/20 | 0.49 |
| ▸ | CA1 | P00915 | 4/20 | 0.49 |
| ▸ | CA2 | P00918 | 4/20 | 0.49 |
| ▸ | CA6 | P23280 | 4/20 | 0.49 |
| ▸ | CA7 | P43166 | 4/20 | 0.49 |
| ▸ | CA13 | Q8N1Q1 | 4/20 | 0.49 |
| ▸ | PLA2G7 | Q13093 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | KDM6B | O15054 | 1/20 | 0.42 |
| ▸ | KDM4A | O75164 | 1/20 | 0.42 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.42 |
| ▸ | HIF1AN | Q9NWT6 | 1/20 | 0.42 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.42 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.42 |
| ▸ | DAO | P14920 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9108890 | 0.83 | KDM4E (0.39) | PLA2G7KDM4EPPARGPPARARAF1 | |
| SCHEMBL3583829 | 0.79 | KDM6B (0.55) | CA12CA1CA2CA6CA7 | |
| SCHEMBL29581998 | 0.78 | CA12 (0.47) | CA12CA1CA2CA6CA7 | |
| SCHEMBL22867798 | 0.76 | CA12 (0.50) | CA12CA1CA2CA6CA7 | |
| SCHEMBL29581389 | 0.76 | CA12 (0.50) | CA12CA1CA2CA6CA7 | |
| SCHEMBL9900452 | 0.76 | PLA2G7 (0.55) | PLA2G7DAOMAPTSMN1; SMN2 | |
| SCHEMBL9904533 | 0.74 | PLA2G7 (0.49) | PLA2G7DAO | |
| SCHEMBL9900816 | 0.73 | PLA2G7 (0.47) | PLA2G7 | |
| SCHEMBL366843 | 0.72 | SCN9A (0.49) | PLA2G7MAPTLMNAPPARGPPARA | |
| SCHEMBL9104734 | 0.72 | PLA2G7 (0.42) | PLA2G7PPARGPPARARAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2649053-A1 | PYRIMIDINONE COMPOUNDS FOR USE IN THE TREATMENT OF DISEASES OR CONDITIONS MEDIATED BY LP - PLA2 | Glaxo Group Limited (GB) | 2013-10-16 | — | — | EP | disclosed |
| WO-2012076435-A1 | PYRIMIDINONE COMPOUNDS FOR USE IN THE TREATMENT OF DISEASES OR CONDITIONS MEDIATED BY LP - PLA2 | GLAXO GROUP LIMITED (GB) | 2012-06-14 | — | — | WO | disclosed |