SCHEMBL9905169

SCHEMBL9905169

O=C(/N=C(/NCc1cc(F)c(F)c(F)c1)Nc1cc(C(F)(F)F)n[nH]1)c1ccccc1

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NTRK1 P04629 2/20 0.36
LMNA P02545 1/20 0.35
ITK Q08881 1/20 0.33
TP53 P04637 3/20 0.33
VNN1 O95497 2/20 0.33
PTGER4 P35408 1/20 0.33
ROCK2 O75116 1/20 0.33
ROCK1 Q13464 1/20 0.33
POLB P06746 1/20 0.33
TSHR P16473 1/20 0.33
HDAC4 P56524 2/20 0.32
HDAC6 Q9UBN7 2/20 0.32
TACR1 P25103 1/20 0.32
EPHX2 P34913 1/20 0.32
MAPT P10636 1/20 0.32
ADORA2A P29274 1/20 0.32
SMN1; SMN2 Q16637 1/20 0.32
PTGS2 P35354 2/20 0.32
HDAC3 O15379 1/20 0.32
HDAC1 Q13547 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9905171 1.00 NTRK1 (0.36) NTRK1LMNAITKTP53VNN1
SCHEMBL9905335 0.91 HPGD (0.35) LMNATP53ROCK2ROCK1POLB
SCHEMBL9905331 0.91 HPGD (0.35) LMNATP53ROCK2ROCK1POLB
SCHEMBL18558219 0.84 MAPT (0.45) TP53VNN1MAPTSMN1; SMN2PTGS2
SCHEMBL18558134 0.79 ALDH1A1 (0.34) LMNAVNN1SMN1; SMN2HDAC2ALDH1A1
SCHEMBL9921096 0.79 MEN1 (0.48) LMNAHDAC6MAPTHDAC3HDAC1
SCHEMBL17088582 0.78 EPHX2 (0.45) ROCK2ROCK1HDAC6EPHX2HDAC3
SCHEMBL17088575 0.78 ROCK2 (0.37) TP53ROCK2ROCK1HDAC4HDAC6
SCHEMBL17088583 0.77 EPHX2 (0.46) ROCK2ROCK1HDAC6EPHX2HDAC3
SCHEMBL19362753 0.75 CCNA2 (0.39) HDAC4EPHX2SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2648511-A1 PYRAZOLYL GUANIDINE F1F0-ATPASE INHIBITORS AND THERAPEUTIC USES THEREOF Lycera Corporation (US) 2013-10-16 EP disclosed
WO-2012078874-A1 PYRAZOLYL GUANIDINE F1F0-ATPASE INHIBITORS AND THERAPEUTIC USES THEREOF LYCERA CORPORATION (US) 2012-06-14 WO disclosed