Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SNCA | P37840 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | RAF1 | P04049 | 4/20 | 0.39 |
| ▸ | BRAF | P15056 | 2/20 | 0.39 |
| ▸ | BAZ1A | Q9NRL2 | 1/20 | 0.36 |
| ▸ | MLLT3 | P42568 | 1/20 | 0.36 |
| ▸ | MLLT1 | Q03111 | 1/20 | 0.36 |
| ▸ | ACR | P10323 | 2/20 | 0.35 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.34 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.34 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9905267 | 1.00 | SNCA (0.41) | SNCAMAPTMEN1NPC1LMNA | |
| SCHEMBL18558394 | 0.91 | RAF1 (0.39) | SNCARAF1BRAFACRHDAC6 | |
| SCHEMBL19360275 | 0.91 | MAPT (0.39) | MAPTNPC1LMNARAF1BRAF | |
| SCHEMBL18558030 | 0.91 | GRM5 (0.41) | SNCAMAPTNPC1RAF1BRAF | |
| SCHEMBL9905362 | 0.90 | SNCA (0.48) | SNCAMAPTLMNAACRTRPV1 | |
| SCHEMBL17088955 | 0.90 | MAPT (0.38) | SNCAMAPTNPC1RAB9ARAF1 | |
| SCHEMBL9905358 | 0.90 | SNCA (0.48) | SNCAMAPTLMNAACRTRPV1 | |
| SCHEMBL17089717 | 0.87 | SNCA (0.41) | SNCAMAPTMEN1NPC1LMNA | |
| SCHEMBL18558123 | 0.86 | SNCA (0.41) | SNCAMAPTRAB9ARAF1BRAF | |
| SCHEMBL18558333 | 0.86 | SNCA (0.41) | SNCAMAPTACRKDM4ETHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2648511-A1 | PYRAZOLYL GUANIDINE F1F0-ATPASE INHIBITORS AND THERAPEUTIC USES THEREOF | Lycera Corporation (US) | 2013-10-16 | — | — | EP | disclosed |
| WO-2012078874-A1 | PYRAZOLYL GUANIDINE F1F0-ATPASE INHIBITORS AND THERAPEUTIC USES THEREOF | LYCERA CORPORATION (US) | 2012-06-14 | — | — | WO | disclosed |