Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 5/20 | 0.39 |
| ▸ | BRAF | P15056 | 3/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | BCHE | P06276 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | SNCA | P37840 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.35 |
| ▸ | ALPL | P05186 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | ACR | P10323 | 2/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
| ▸ | PPARD | Q03181 | 1/20 | 0.35 |
| ▸ | PPARA | Q07869 | 1/20 | 0.35 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18558596 | 0.92 | RAF1 (0.42) | RAF1BRAFMAPK1ACR | |
| SCHEMBL18558387 | 0.91 | RAF1 (0.41) | RAF1HDAC6BCHEACHEALPL | |
| SCHEMBL9905267 | 0.91 | SNCA (0.41) | RAF1BRAFHDAC6SNCAACR | |
| SCHEMBL9905271 | 0.91 | SNCA (0.41) | RAF1BRAFHDAC6SNCAACR | |
| SCHEMBL18558388 | 0.91 | MAPT (0.39) | RAF1HDAC6BCHEACHEALPL | |
| SCHEMBL18558030 | 0.91 | GRM5 (0.41) | RAF1BRAFSNCAACR | |
| SCHEMBL18558333 | 0.90 | SNCA (0.41) | HDAC6BCHEACHESNCAALPL | |
| SCHEMBL18558154 | 0.88 | GRM5 (0.42) | RAF1HDAC6BCHEACHEALPL | |
| SCHEMBL18558156 | 0.88 | MAPT (0.36) | RAF1HDAC6BCHEACHEMAPK1 | |
| SCHEMBL18557825 | 0.86 | ALPL (0.38) | RAF1BRAFHDAC6BCHEACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9580388-B2 | Pyrazolyl guanidine F1F0-ATPase inhibitors and therapeutic uses thereof | LYCERA CORPORATION (US) | 2017-02-28 | — | — | US | disclosed |