Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS3 | P29474 | 2/20 | 0.43 |
| ▸ | NOS1 | P29475 | 2/20 | 0.43 |
| ▸ | NOS2 | P35228 | 2/20 | 0.43 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.38 |
| ▸ | GRM5 | P41594 | 2/20 | 0.35 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.35 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.34 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
| ▸ | MTOR | P42345 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9902856 | 0.80 | GRM5 (0.47) | GRM5ATAD2PDGFRBPDGFRAALDH1A1 | |
| SCHEMBL9903498 | 0.80 | GRM5 (0.46) | GRM5PDGFRBPDGFRATGFBR1 | |
| SCHEMBL9903708 | 0.79 | ABL1 (0.40) | GRM5PDGFRBPDGFRAALDH1A1 | |
| SCHEMBL9903391 | 0.79 | MTOR (0.45) | PIK3CAMTOR | |
| SCHEMBL23283107 | 0.78 | GRM5 (0.49) | NOS3NOS1NOS2MAP4K4GRM5 | |
| SCHEMBL9902619 | 0.78 | GRM5 (0.51) | GRM5PDGFRBPDGFRAALDH1A1 | |
| SCHEMBL9903420 | 0.78 | GRM5 (0.55) | GRM5PDGFRBPDGFRAALDH1A1 | |
| SCHEMBL9902735 | 0.76 | PIK3CA (0.42) | GRM5PDGFRBPDGFRAPIK3CAMTOR | |
| SCHEMBL9902843 | 0.75 | AAK1 (0.50) | GRM5PIK3CAMTOR | |
| SCHEMBL9903388 | 0.75 | ALDH1A1 (0.39) | GRM5PDGFRBALDH1A1TGFBR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2462142-A1 | METABOTROPIC GLUTAMATE RECEPTOR MODULATORS | Merz Pharma GmbH & Co. KGaA (DE) | 2012-06-13 | — | — | EP | claimed |