Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.32 |
| ▸ | AR | P10275 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | F10 | P00742 | 1/20 | 0.32 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | CCR8 | P51685 | 2/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | MAOB | P27338 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2643833 | 0.83 | GCK (0.40) | GCKFFAR4 | |
| SCHEMBL645250 | 0.75 | GCK (0.67) | GCKKCNH2 | |
| SCHEMBL644377 | 0.71 | GCK (0.52) | GCKALDH1A1FFAR4F10KDM4E | |
| SCHEMBL2644207 | 0.71 | LMNA (0.39) | GCKFFAR4LMNAF10 | |
| SCHEMBL643703 | 0.70 | GCK (0.53) | GCKMAPTFFAR4LMNAF10 | |
| SCHEMBL17193997 | 0.66 | MAOB (0.37) | MAPTALDH1A1FFAR4LMNACCR8 | |
| SCHEMBL2643504 | 0.65 | GCK (0.41) | GCKFFAR4 | |
| SCHEMBL2645034 | 0.65 | GCK (0.42) | GCKALDH1A1FFAR4F10KDM4E | |
| SCHEMBL645682 | 0.64 | GCK (0.42) | GCKMAPTLMNAKCNH2 | |
| SCHEMBL6679346 | 0.64 | CCR8 (0.40) | MAPTALDH1A1LMNACCR8KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2463283-B1 | Fused phenyl Amido heterocyclic compounds for the prevention and treatment of glucokinase-mediated diseases | PFIZER PROD INC (US) | 2014-06-11 | — | — | EP | disclosed |
| EP-2463283-A1 | Fused phenyl Amido heterocyclic compounds for the prevention and treatment of glucokinase-mediated diseases | Pfizer Products Inc. (US) | 2012-06-13 | — | — | EP | disclosed |