SCHEMBL643703

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

	Compound	similarity	top predicted	shared targets
	SCHEMBL644377	0.90	GCK (0.52)	GCKLPAR1LPAR5SMN1; SMN2EZH2
	SCHEMBL643223	0.86	GCK (0.44)	GCKLPAR1LPAR5TSHRLMNA
	SCHEMBL643650	0.86	GCK (0.52)	GCKTSHRLMNAMAPTRAB9A
	SCHEMBL643908	0.84	GCK (0.72)	GCKCPS1SCN9AGPR119
	SCHEMBL642115	0.83	GCK (0.49)	GCKTSHRLMNAMAPTRAB9A
	SCHEMBL2669366	0.83	GCK (0.50)	GCKLPAR1LPAR5EZH2FFAR4
	SCHEMBL643673	0.83	GCK (0.59)	GCKTSHRLMNAMAPTRAB9A
	SCHEMBL642567	0.83	GCK (0.59)	GCKTSHRRAB9ASMN1; SMN2NPSR1
	SCHEMBL645031	0.83	GCK (0.48)	GCKTSHRLMNAMAPTRAB9A
	SCHEMBL643599	0.82	GCK (0.65)	GCKRAB9ASMN1; SMN2F10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.