Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 13/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.57 |
| ▸ | LMNA | P02545 | 4/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 2/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | RECQL | P46063 | 1/20 | 0.50 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL961124 | 0.77 | SIRT6 (0.77) | MAPTALDH1A1CYP1A2CYP2C19L3MBTL1 | |
| SCHEMBL30416098 | 0.77 | HPGD (0.68) | MAPTALDH1A1CYP1A2CYP2C19L3MBTL1 | |
| SCHEMBL28137192 | 0.76 | SIRT6 (0.75) | MAPTALDH1A1CYP1A2CYP2C19L3MBTL1 | |
| SCHEMBL12478451 | 0.76 | SIRT6 (0.75) | MAPTALDH1A1CYP1A2CYP2C19L3MBTL1 | |
| SCHEMBL25855470 | 0.75 | HPGD (0.73) | MAPTALDH1A1CYP1A2CYP2C19L3MBTL1 | |
| SCHEMBL12757010 | 0.74 | TSHR (0.53) | MAPTALDH1A1L3MBTL1LMNAMAPK1 | |
| SCHEMBL10651251 | 0.74 | HPGD (0.68) | MAPTALDH1A1CYP1A2CYP2C19L3MBTL1 | |
| SCHEMBL10651255 | 0.74 | HPGD (0.68) | MAPTALDH1A1CYP1A2CYP2C19L3MBTL1 | |
| SCHEMBL7030430 | 0.73 | MAPT (0.52) | MAPTALDH1A1CYP1A2CYP2C19L3MBTL1 | |
| SCHEMBL7033936 | 0.73 | MAPT (0.52) | MAPTALDH1A1CYP1A2CYP2C19L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011072241-A9 | 4-OXO-1H-QUINOLINE-3-CARBOXAMIDES AS MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-06-14 | — | — | WO | disclosed |