Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 14/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | PTGER1 | P34995 | 2/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | STAT3 | P40763 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.31 |
| ▸ | GRM5 | P41594 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9905213 | 0.92 | MAPK14 (0.39) | MAPK14SMN1; SMN2MCHR1GRM5 | |
| SCHEMBL9905679 | 0.90 | MAPK14 (0.38) | MAPK14SMN1; SMN2PTGER1CYP2C9LMNA | |
| SCHEMBL9901165 | 0.89 | MAPK14 (0.48) | MAPK14 | |
| SCHEMBL9901647 | 0.87 | MAOB (0.35) | MAPK14POLBMAPT | |
| SCHEMBL9109911 | 0.85 | MAPK14 (0.66) | MAPK14 | |
| SCHEMBL9902349 | 0.85 | MAOB (0.36) | SMN1; SMN2PTGER1CYP2C9MAPTHTT | |
| SCHEMBL9905675 | 0.85 | MAPK14 (0.44) | MAPK14SMN1; SMN2PTGER1CYP2C9 | |
| SCHEMBL9901203 | 0.84 | GABRG2 (0.30) | GRM5 | |
| SCHEMBL9111548 | 0.81 | MAPK14 (0.52) | MAPK14SMN1; SMN2PTGER1CYP2C9LMNA | |
| SCHEMBL9902403 | 0.81 | MAPK14 (0.47) | MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2648516-A1 | SUBSTITUTED PYRIDINONE-PYRIDINYL COMPOUNDS | Confluence Life Sciences, Inc. (US) | 2013-10-16 | — | — | EP | disclosed |
| WO-2012078684-A1 | SUBSTITUTED PYRIDINONE-PYRIDINYL COMPOUNDS | CONFLUENCE LIFE SCIENCES, INC. (US) | 2012-06-14 | — | — | WO | disclosed |