SCHEMBL9905679

SCHEMBL9905679

Cc1c(OCc2ccc(F)cc2)c(Cl)c(=O)n(-c2ccnc(-c3ccnc(C(C)C)n3)c2)c1C

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPK14 Q16539 4/20 0.38
SMN1; SMN2 Q16637 1/20 0.35
MAPKAPK2 P49137 3/20 0.34
PTGER1 P34995 2/20 0.32
HPD P32754 1/20 0.32
MAPKAPK5 Q8IW41 1/20 0.32
MCHR1 Q99705 2/20 0.31
USP2 O75604 1/20 0.31
ALDH1A1 P00352 1/20 0.31
CYP1A2 P05177 1/20 0.31
CYP3A4 P08684 1/20 0.31
CYP2C9 P11712 1/20 0.31
TSHR P16473 1/20 0.31
GRM5 P41594 2/20 0.31
LMNA P02545 1/20 0.31
MAPT P10636 1/20 0.31
HPGD P15428 1/20 0.31
ALOX12 P18054 1/20 0.31
TBXA2R P21731 1/20 0.31
PTGER4 P35408 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9905213 0.93 MAPK14 (0.39) MAPK14SMN1; SMN2MCHR1GRM5ACACB
SCHEMBL9905649 0.90 MAPK14 (0.46) MAPK14SMN1; SMN2PTGER1MCHR1CYP2C9
SCHEMBL9902573 0.89 MAPKAPK2 (0.45) MAPK14MAPKAPK2
SCHEMBL9901769 0.87 MAOB (0.36) ALDH1A1CYP1A2CYP3A4GRM5LMNA
SCHEMBL9108533 0.85 MAPK14 (0.52) MAPK14MAPKAPK2PTGER1MAPKAPK5TBXA2R
SCHEMBL9901304 0.85 MAOB (0.37) SMN1; SMN2PTGER1ALDH1A1CYP1A2CYP3A4
SCHEMBL9905630 0.84 MAPKAPK2 (0.48) MAPK14SMN1; SMN2MAPKAPK2PTGER1HPD
SCHEMBL9901297 0.83 BRD4 (0.31) GRM5
SCHEMBL9901449 0.83 NMT1 (0.41) ALDH1A1TSHRKDM5B
SCHEMBL9111548 0.82 MAPK14 (0.52) MAPK14SMN1; SMN2MAPKAPK2PTGER1MAPKAPK5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2648516-A1 SUBSTITUTED PYRIDINONE-PYRIDINYL COMPOUNDS Confluence Life Sciences, Inc. (US) 2013-10-16 EP disclosed
WO-2012078684-A1 SUBSTITUTED PYRIDINONE-PYRIDINYL COMPOUNDS CONFLUENCE LIFE SCIENCES, INC. (US) 2012-06-14 WO disclosed