Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.33 |
| ▸ | MMP2 | P08253 | 1/20 | 0.32 |
| ▸ | ANPEP | P15144 | 1/20 | 0.32 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.31 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.31 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.31 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.31 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.31 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.30 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.30 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9905680 | 1.00 | TP53 (0.39) | TP53SLC1A2MMP2ANPEPCHRNB2 | |
| SCHEMBL10443020 | 0.79 | SLC1A2 (0.50) | SLC1A2 | |
| SCHEMBL28948795 | 0.74 | CHRNB2 (0.40) | SLC1A2CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL178593 | 0.73 | SPHK1 (0.38) | SLC1A2CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL2976643 | 0.73 | SLC1A2 (0.38) | TP53SLC1A2CHRNB2CHRNA4CHRNB4 | |
| SCHEMBL201157 | 0.73 | SPHK1 (0.38) | SLC1A2CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL6026317 | 0.73 | SPHK1 (0.38) | SLC1A2CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL2428831 | 0.73 | SLC1A2 (0.38) | TP53SLC1A2CHRNB2CHRNA4CHRNB4 | |
| SCHEMBL201158 | 0.73 | SPHK1 (0.38) | SLC1A2CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL19144063 | 0.73 | SLC1A2 (0.38) | TP53SLC1A2CHRNB2CHRNA4CHRNB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011072241-A9 | 4-OXO-1H-QUINOLINE-3-CARBOXAMIDES AS MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-06-14 | — | — | WO | disclosed |