Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.42 |
| ▸ | SMO | Q99835 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 3/20 | 0.42 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.41 |
| ▸ | PPARA | Q07869 | 3/20 | 0.41 |
| ▸ | PPARD | Q03181 | 3/20 | 0.41 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.41 |
| ▸ | PTGES | O14684 | 2/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.40 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.40 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.40 |
| ▸ | GPR34 | Q9UPC5 | 1/20 | 0.39 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.39 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.39 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9905738 | 1.00 | MRGPRX4 (0.42) | MRGPRX4MAPK14SMOMAOBSLC6A5 | |
| SCHEMBL9905736 | 1.00 | MRGPRX4 (0.42) | MRGPRX4MAPK14SMOMAOBSLC6A5 | |
| SCHEMBL9905780 | 0.92 | BCL2L1 (0.43) | MRGPRX4MAPK14SMOMAOBPPARA | |
| SCHEMBL9905384 | 0.92 | BCL2L1 (0.43) | MRGPRX4MAPK14SMOMAOBPPARA | |
| SCHEMBL9905383 | 0.92 | BCL2L1 (0.43) | MRGPRX4MAPK14SMOMAOBPPARA | |
| SCHEMBL17088956 | 0.91 | ERAP1 (0.44) | MAPK14SMOMAOBMCL1PTGES | |
| SCHEMBL9920729 | 0.90 | MAPK14 (0.39) | MRGPRX4MAPK14SMOMAOBSLC6A5 | |
| SCHEMBL18558030 | 0.88 | GRM5 (0.41) | MAPK14 | |
| SCHEMBL9905766 | 0.88 | PPIA (0.40) | MRGPRX4PPARDPPARG | |
| SCHEMBL9905250 | 0.88 | PPIA (0.40) | MRGPRX4PPARDPPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2648511-A1 | PYRAZOLYL GUANIDINE F1F0-ATPASE INHIBITORS AND THERAPEUTIC USES THEREOF | Lycera Corporation (US) | 2013-10-16 | — | — | EP | disclosed |
| WO-2012078874-A1 | PYRAZOLYL GUANIDINE F1F0-ATPASE INHIBITORS AND THERAPEUTIC USES THEREOF | LYCERA CORPORATION (US) | 2012-06-14 | — | — | WO | disclosed |