Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.43 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 2/20 | 0.42 |
| ▸ | IGF1R | P08069 | 1/20 | 0.40 |
| ▸ | MET | P08581 | 1/20 | 0.40 |
| ▸ | SRC | P12931 | 1/20 | 0.40 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.40 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.40 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.40 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.40 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.39 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.39 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.39 |
| ▸ | F10 | P00742 | 1/20 | 0.39 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.38 |
| ▸ | PPARA | Q07869 | 1/20 | 0.38 |
| ▸ | GPR132 | Q9UNW8 | 1/20 | 0.38 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.38 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.38 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9905384 | 1.00 | BCL2L1 (0.43) | BCL2L1MCL1MAOBIGF1RMET | |
| SCHEMBL9905383 | 1.00 | BCL2L1 (0.43) | BCL2L1MCL1MAOBIGF1RMET | |
| SCHEMBL19360274 | 0.92 | MRGPRX4 (0.42) | BCL2L1MCL1MAOBPDK1PDK2 | |
| SCHEMBL9905736 | 0.92 | MRGPRX4 (0.42) | BCL2L1MCL1MAOBMRGPRX4NR4A2 | |
| SCHEMBL9905738 | 0.92 | MRGPRX4 (0.42) | BCL2L1MCL1MAOBMRGPRX4NR4A2 | |
| SCHEMBL9905739 | 0.92 | MRGPRX4 (0.42) | BCL2L1MCL1MAOBMRGPRX4NR4A2 | |
| SCHEMBL17088954 | 0.91 | MAPT (0.41) | MAOBPDK1PDK2PDK3PDK4 | |
| SCHEMBL18558030 | 0.87 | GRM5 (0.41) | MAPK14 | |
| SCHEMBL9905766 | 0.87 | PPIA (0.40) | MRGPRX4PPARD | |
| SCHEMBL9905250 | 0.87 | PPIA (0.40) | MRGPRX4PPARD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2648511-A1 | PYRAZOLYL GUANIDINE F1F0-ATPASE INHIBITORS AND THERAPEUTIC USES THEREOF | Lycera Corporation (US) | 2013-10-16 | — | — | EP | disclosed |
| WO-2012078874-A1 | PYRAZOLYL GUANIDINE F1F0-ATPASE INHIBITORS AND THERAPEUTIC USES THEREOF | LYCERA CORPORATION (US) | 2012-06-14 | — | — | WO | disclosed |