Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPIA | P62937 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.39 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.39 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.39 |
| ▸ | RXRA | P19793 | 1/20 | 0.38 |
| ▸ | RXRB | P28702 | 1/20 | 0.38 |
| ▸ | RXRG | P48443 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.38 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.38 |
| ▸ | PTGER1 | P34995 | 4/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
| ▸ | PPARD | Q03181 | 1/20 | 0.37 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.37 |
| ▸ | FEN1 | P39748 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9905253 | 1.00 | PPIA (0.40) | PPIAMAPTPOLBPTPN1PTPN2 | |
| SCHEMBL9905250 | 1.00 | PPIA (0.40) | PPIAMAPTPOLBPTPN1PTPN2 | |
| SCHEMBL19360272 | 0.93 | MAPT (0.41) | MAPTPOLBRXRARXRBRXRG | |
| SCHEMBL17088952 | 0.91 | MAPT (0.45) | MAPTPOLBRXRARXRBRXRG | |
| SCHEMBL9905739 | 0.88 | MRGPRX4 (0.42) | MRGPRX4PPARGPPARD | |
| SCHEMBL9905736 | 0.88 | MRGPRX4 (0.42) | MRGPRX4PPARGPPARD | |
| SCHEMBL9905738 | 0.88 | MRGPRX4 (0.42) | MRGPRX4PPARGPPARD | |
| SCHEMBL9905383 | 0.87 | BCL2L1 (0.43) | MRGPRX4PPARD | |
| SCHEMBL9905384 | 0.87 | BCL2L1 (0.43) | MRGPRX4PPARD | |
| SCHEMBL9905780 | 0.87 | BCL2L1 (0.43) | MRGPRX4PPARD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2648511-A1 | PYRAZOLYL GUANIDINE F1F0-ATPASE INHIBITORS AND THERAPEUTIC USES THEREOF | Lycera Corporation (US) | 2013-10-16 | — | — | EP | disclosed |
| WO-2012078874-A1 | PYRAZOLYL GUANIDINE F1F0-ATPASE INHIBITORS AND THERAPEUTIC USES THEREOF | LYCERA CORPORATION (US) | 2012-06-14 | — | — | WO | disclosed |