Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | RXRA | P19793 | 1/20 | 0.48 |
| ▸ | RXRB | P28702 | 1/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 3/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | BRD4 | O60885 | 1/20 | 0.46 |
| ▸ | BRD2 | P25440 | 1/20 | 0.46 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.46 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.44 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.43 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.43 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.43 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5698013 | 0.84 | RXRA (0.55) | MAPTKDM4EGAARXRARXRB | |
| SCHEMBL6313369 | 0.81 | BRD4 (0.50) | MAPTKDM4EGAARXRARXRB | |
| SCHEMBL27995883 | 0.80 | RXRA (0.48) | MAPTKDM4EGAARXRARXRB | |
| SCHEMBL398405 | 0.80 | TP53 (0.56) | MAPTKDM4EGAARXRARXRB | |
| SCHEMBL11017769 | 0.80 | RXRA (0.51) | MAPTKDM4EGAARXRARXRB | |
| SCHEMBL29426410 | 0.80 | RXRA (0.66) | MAPTKDM4EGAARXRARXRB | |
| SCHEMBL9260410 | 0.80 | RXRA (0.66) | MAPTKDM4EGAARXRARXRB | |
| SCHEMBL30963915 | 0.79 | TP53 (0.51) | MAPTKDM4EGAARXRARXRB | |
| SCHEMBL30338775 | 0.78 | RXRA (0.70) | MAPTKDM4EGAARXRARXRB | |
| SCHEMBL203120 | 0.78 | RXRA (0.70) | MAPTKDM4EGAARXRARXRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011072241-A9 | 4-OXO-1H-QUINOLINE-3-CARBOXAMIDES AS MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-06-14 | — | — | WO | disclosed |