Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.46 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | HPGD | P15428 | 3/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | IP6K1 | Q92551 | 3/20 | 0.43 |
| ▸ | IP6K3 | Q96PC2 | 3/20 | 0.43 |
| ▸ | IP6K2 | Q9UHH9 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.42 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.42 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9907506 | 0.85 | TP53 (0.52) | TDP1ALDH1A1HPGDPOLBL3MBTL1 | |
| SCHEMBL9907858 | 0.80 | HTR5A (0.64) | HTR5A | |
| SCHEMBL9907568 | 0.80 | IP6K1 (0.52) | ALDH1A1HPGDPOLBL3MBTL1KDM4E | |
| SCHEMBL9907601 | 0.78 | HTR5A (0.47) | TDP1NAPRTALDH1A1HPGDPOLB | |
| SCHEMBL9907599 | 0.78 | HTR5A (0.58) | ALDH1A1HPGDPOLBL3MBTL1KDM4E | |
| SCHEMBL9907501 | 0.78 | IP6K1 (0.49) | NAPRTALDH1A1HPGDKDM4EIP6K1 | |
| SCHEMBL9907575 | 0.77 | HTR5A (0.47) | TDP1ALDH1A1HPGDPOLBL3MBTL1 | |
| SCHEMBL9907584 | 0.76 | HTR5A (0.46) | TDP1ALDH1A1HPGDPOLBL3MBTL1 | |
| SCHEMBL9907725 | 0.76 | PLAU (0.49) | TDP1NAPRTALDH1A1HPGDPOLB | |
| SCHEMBL9907569 | 0.76 | HTR5A (0.47) | NAPRTALDH1A1KDM4EIP6K1IP6K3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8853242-B2 | Nitrogenous-ring acylguanidine derivative | ASTELLAS PHARMA INC. (JP) | 2014-10-07 | — | — | US | disclosed |
| US-20120142727-A1 | NITROGENOUS-RING ACYLGUANIDINE DERIVATIVE | ASTELLAS PHARMA INC. (JP) | 2012-06-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120142727-A1 | NITROGENOUS-RING ACYLGUANIDINE DERIVATIVE | HTR5A, HTR2A, HTR1E | TDP1 964/4885NAPRT 1077/4885ALDH1A1 1799/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.