Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K4 | P45985 | 1/20 | 0.45 |
| ▸ | HTR5A | P47898 | 2/20 | 0.43 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.42 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.42 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | BRD2 | P25440 | 1/20 | 0.39 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.39 |
| ▸ | ALPL | P05186 | 1/20 | 0.39 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9907730 | 0.91 | MAP2K4 (0.46) | MAP2K4HTR5ACSNK2A2CSNK2BCSNK2A1 | |
| SCHEMBL9907675 | 0.89 | HTR5A (0.54) | MAP2K4HTR5ACSNK2A1MAPTSLC2A1 | |
| SCHEMBL9907754 | 0.89 | HTR5A (0.47) | MAP2K4HTR5ACSNK2A2CSNK2BCSNK2A1 | |
| SCHEMBL9909289 | 0.87 | MEN1 (0.45) | MAP2K4HTR5ACSNK2A2CSNK2BNPC1 | |
| SCHEMBL9907714 | 0.87 | HTR5A (0.55) | MAP2K4HTR5ACSNK2A2CSNK2BCSNK2A1 | |
| SCHEMBL9907758 | 0.87 | HTR5A (0.43) | MAP2K4HTR5ACSNK2A2CSNK2BCSNK2A1 | |
| SCHEMBL9907708 | 0.87 | KDM4C (0.47) | MAP2K4HTR5ACSNK2A2CSNK2BMAPT | |
| SCHEMBL9908020 | 0.86 | HTR5A (0.48) | MAP2K4HTR5ACSNK2A2CSNK2BCSNK2A1 | |
| SCHEMBL9907676 | 0.86 | HTR5A (0.40) | MAP2K4HTR5ACSNK2A2CSNK2BCSNK2A1 | |
| SCHEMBL9907679 | 0.85 | HTR5A (0.44) | MAP2K4HTR5ACSNK2A2CSNK2BCSNK2A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8853242-B2 | Nitrogenous-ring acylguanidine derivative | ASTELLAS PHARMA INC. (JP) | 2014-10-07 | — | — | US | disclosed |
| US-20120142727-A1 | NITROGENOUS-RING ACYLGUANIDINE DERIVATIVE | ASTELLAS PHARMA INC. (JP) | 2012-06-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120142727-A1 | NITROGENOUS-RING ACYLGUANIDINE DERIVATIVE | HTR5A, HTR2A, HTR1E | MAP2K4 3941/4885HTR5A 1/4885CSNK2A2 4132/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.