Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR5A | P47898 | 12/20 | 0.59 |
| ▸ | KMO | O15229 | 2/20 | 0.46 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.42 |
| ▸ | RORC | P51449 | 2/20 | 0.40 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.40 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.40 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9907756 | 0.91 | HTR5A (0.50) | HTR5AKMOMRGPRX4RORCCSNK2A1 | |
| SCHEMBL9907694 | 0.90 | HTR5A (0.59) | HTR5ARORCCSNK2A2CSNK2BAURKA | |
| SCHEMBL9907640 | 0.90 | HTR5A (0.71) | HTR5ARORCCSNK2A2CSNK2BAURKA | |
| SCHEMBL9907719 | 0.89 | HTR5A (0.58) | HTR5ARORCCSNK2A2CSNK2BAURKA | |
| SCHEMBL9907764 | 0.89 | HTR5A (0.57) | HTR5ACSNK2A1CSNK2A2CSNK2B | |
| SCHEMBL9907734 | 0.86 | HTR5A (0.55) | HTR5ARORCCSNK2A2CSNK2B | |
| SCHEMBL9907726 | 0.86 | HTR5A (0.55) | HTR5ARORCCSNK2A1 | |
| SCHEMBL9907695 | 0.86 | HTR5A (0.65) | HTR5ARORCAURKA | |
| SCHEMBL9907729 | 0.85 | HTR5A (0.55) | HTR5AKMORORCCSNK2A2CSNK2B | |
| SCHEMBL9907962 | 0.84 | HTR5A (0.84) | HTR5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8853242-B2 | Nitrogenous-ring acylguanidine derivative | ASTELLAS PHARMA INC. (JP) | 2014-10-07 | — | — | US | disclosed |
| US-8853242-B2 | Nitrogenous-ring acylguanidine derivative | ASTELLAS PHARMA INC. (JP) | 2014-10-07 | — | — | US | disclosed |
| US-20120142727-A1 | NITROGENOUS-RING ACYLGUANIDINE DERIVATIVE | ASTELLAS PHARMA INC. (JP) | 2012-06-07 | — | — | US | disclosed |
| US-20120142727-A1 | NITROGENOUS-RING ACYLGUANIDINE DERIVATIVE | ASTELLAS PHARMA INC. (JP) | 2012-06-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120142727-A1 | NITROGENOUS-RING ACYLGUANIDINE DERIVATIVE | HTR5A, HTR2A, HTR1E | HTR5A 1/4885KMO 559/4885MRGPRX4 1163/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.