Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR5A | P47898 | 14/20 | 0.69 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.42 |
| ▸ | HTR2B | P41595 | 2/20 | 0.39 |
| ▸ | MPO | P05164 | 1/20 | 0.39 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.39 |
| ▸ | HTR7 | P34969 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9907902 | 0.92 | HTR5A (0.60) | HTR5AGRM2HTR2BMPOPTPN11 | |
| SCHEMBL9907886 | 0.90 | HTR5A (0.78) | HTR5AHTR2BMPOHTR7 | |
| SCHEMBL9907898 | 0.86 | HTR5A (0.64) | HTR5AHTR2BHTR7 | |
| SCHEMBL9907644 | 0.86 | HTR5A (0.48) | HTR5AGRM2PTPN11 | |
| SCHEMBL9907895 | 0.84 | HTR5A (0.76) | HTR5AMPO | |
| SCHEMBL9907907 | 0.84 | HTR5A (0.60) | HTR5AHTR2BHTR7 | |
| SCHEMBL9907831 | 0.84 | HTR5A (0.71) | HTR5A | |
| SCHEMBL9907868 | 0.84 | HTR5A (0.68) | HTR5AMPO | |
| SCHEMBL9907883 | 0.82 | HTR5A (0.73) | HTR5AHTR2BHTR7 | |
| SCHEMBL9108054 | 0.82 | HTR5A (1.00) | HTR5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8853242-B2 | Nitrogenous-ring acylguanidine derivative | ASTELLAS PHARMA INC. (JP) | 2014-10-07 | — | — | US | disclosed |
| US-8853242-B2 | Nitrogenous-ring acylguanidine derivative | ASTELLAS PHARMA INC. (JP) | 2014-10-07 | — | — | US | disclosed |
| US-20120142727-A1 | NITROGENOUS-RING ACYLGUANIDINE DERIVATIVE | ASTELLAS PHARMA INC. (JP) | 2012-06-07 | — | — | US | disclosed |
| US-20120142727-A1 | NITROGENOUS-RING ACYLGUANIDINE DERIVATIVE | ASTELLAS PHARMA INC. (JP) | 2012-06-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120142727-A1 | NITROGENOUS-RING ACYLGUANIDINE DERIVATIVE | HTR5A, HTR2A, HTR1E | HTR5A 1/4885GRM2 109/4885HTR2B 6/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.