Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 14/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | IDH1 | O75874 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL990723 | 1.00 | GRM5 (0.46) | GRM5L3MBTL1NPC1RAB9AIDH1 | |
| SCHEMBL3376157 | 0.87 | GRM5 (0.46) | GRM5L3MBTL1NPC1RAB9A | |
| SCHEMBL992597 | 0.83 | GRM5 (0.46) | GRM5NPC1RAB9ALMNATSHR | |
| SCHEMBL991485 | 0.83 | GRM5 (0.46) | GRM5NPC1RAB9ALMNATSHR | |
| SCHEMBL992315 | 0.83 | GRM5 (0.45) | GRM5L3MBTL1NPC1RAB9AMEN1 | |
| SCHEMBL990298 | 0.83 | GRM5 (0.45) | GRM5L3MBTL1NPC1RAB9AMEN1 | |
| SCHEMBL990340 | 0.82 | L3MBTL1 (0.59) | GRM5L3MBTL1NPC1RAB9AMEN1 | |
| SCHEMBL16390663 | 0.81 | EPHX2 (0.53) | GRM5MEN1LMNAEPHX2KMT2A | |
| SCHEMBL990289 | 0.81 | EPHX2 (0.53) | GRM5MEN1LMNAEPHX2KMT2A | |
| SCHEMBL990822 | 0.80 | NPC1 (0.48) | GRM5L3MBTL1NPC1RAB9ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2272509-A1 | New Uses of metabotropic glutamate receptors | Novartis AG (CH) | 2011-01-12 | — | — | EP | disclosed |
| EP-1877365-A1 | ACETYLENE DERIVATIVES | Novartis AG (CH) | 2008-01-16 | — | — | EP | disclosed |
| WO-2006114262-A1 | ACETYLENE DERIVATIVES | NOVARTIS AG (CH) | 2006-11-02 | — | — | WO | disclosed |