Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | CLK1 | P49759 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 4/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | AHR | P35869 | 1/20 | 0.37 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL991485 | 1.00 | GRM5 (0.46) | GRM5ALDH1A1NPC1RAB9AHSD17B10 | |
| SCHEMBL990801 | 0.90 | GRM5 (0.48) | GRM5ALDH1A1 | |
| SCHEMBL3375215 | 0.84 | GRM5 (0.48) | GRM5NPC1RAB9A | |
| SCHEMBL3371621 | 0.84 | GRM5 (0.48) | GRM5NPC1RAB9A | |
| SCHEMBL990298 | 0.84 | GRM5 (0.45) | GRM5NPC1RAB9ALMNAMAPT | |
| SCHEMBL992315 | 0.84 | GRM5 (0.45) | GRM5NPC1RAB9ALMNAMAPT | |
| SCHEMBL990891 | 0.83 | GRM5 (0.46) | GRM5NPC1RAB9ATSHRLMNA | |
| SCHEMBL990723 | 0.83 | GRM5 (0.46) | GRM5NPC1RAB9ATSHRLMNA | |
| SCHEMBL990340 | 0.81 | L3MBTL1 (0.59) | GRM5NPC1RAB9A | |
| SCHEMBL2839746 | 0.81 | GRM5 (0.43) | GRM5ALDH1A1NPC1RAB9AHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2272509-A1 | New Uses of metabotropic glutamate receptors | Novartis AG (CH) | 2011-01-12 | — | — | EP | disclosed |