⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12704663 | 1.00 | — | — | |
| SCHEMBL9876742 | 0.72 | — | — | |
| SCHEMBL11340891 | 0.70 | — | — | |
| SCHEMBL11009755 | 0.68 | ALOX15 (0.31) | — | |
| SCHEMBL11403878 | 0.67 | TSHR (0.36) | — | |
| SCHEMBL11150024 | 0.67 | — | — | |
| SCHEMBL11221717 | 0.67 | — | — | |
| SCHEMBL11221714 | 0.67 | — | — | |
| SCHEMBL11224093 | 0.67 | TSHR (0.36) | — | |
| SCHEMBL11089412 | 0.67 | ALOX15 (0.39) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8198463-B2 | Process for the preparation of 6,6-dimethyl-3-azabicyclo-[3.3.0]-hexane compounds and enantiomeric salts thereof | SCHERING CORPORATION (US) | 2012-06-12 | — | — | US | disclosed |
| US-8158807-B2 | Process for the preparation of 6,6-dimethyl-3-azabicyclo-[3.1.0]-hexane compounds utilizing bisulfite intermediate | SCHERING CORPORATION (US) | 2012-04-17 | — | — | US | disclosed |
| US-20100256393-A1 | PROCESS FOR THE PREPARATION OF 6,6- DIMETHYL-3-AZABICYCLO-[3.1.0]-HEXANE COMPOUNDS AND ENANTIOMERIC SALTS THEREOF | SCHERING CORPORATION (US) | 2010-10-07 | — | — | US | disclosed |
| US-20100145069-A1 | PROCESS FOR THE PREPARATION OF 6,6-DIMETHYL-3-AZABICYCLO-[3.1.0]- HEXANE COMPOUNDS UTILIZING BISULFITE INTERMEDIATE | SCHERING CORPORATION (US) | 2010-06-10 | — | — | US | disclosed |
| US-7728165-B2 | Process and intermediates for the preparation of (1R,2S,5S)-6,6-dimethyl-3-azabicyclo[3,1,0]hexane-2-carboxylates or salts thereof | SCHERING PLOUGH CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7723531-B2 | Process for the preparation of 6,6-dimethyl-3-azabicyclo-[3.1.0]-hexane compounds and enantiomeric salts thereof | SCHERING CORPORATION (US) | 2010-05-25 | — | — | US | disclosed |
| US-20090247784-A1 | PROCESS AND INTERMEDIATES FOR THE PREPARATION OF (1R,2S,5S)-6,6-DIMETHYL-3-AZABICYCLO[3,1,0]HEXANE-2-CARBOXYLATES OR SALTS THEREOF | PARK JEONGHAN | 2009-10-01 | — | — | US | disclosed |
| US-20090240063-A1 | Process For The Preparation Of 6,6-Dimethyl-3-Azabicyclo-[3.1.0]-Hexane Compounds ... | MERCK SHARP & DOHME CORP. | 2009-09-24 | — | — | US | disclosed |
| US-7569705-B2 | Process and intermediates for the preparation of (1R,2S,5S)-6,6-dimethyl-3-azabicyclo[3,1,0]hexane-2-carboxylates for salts thereof | SCHERING CORPORATION (US) | 2009-08-04 | — | — | US | disclosed |
| US-20080114179-A1 | Process and intermediates for the preparation of (1R,2S,5S)-6,6-dimethyl-3-azabicyclo[3,1,0]hexane-2-carboxylates for salts thereof | MERCK SHARP & DOHME CORP. | 2008-05-15 | — | — | US | disclosed |
| US-7309717-B2 | Process and intermediates for the preparation of (1R,2S,5S)-6,6-dimethyl-3-azabicyclo[3,1,0]hexane-2-carboxylates or salts thereof | SCHERING CORPORATION (US) | 2007-12-18 | — | — | US | disclosed |