Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR5A | P47898 | 4/20 | 0.50 |
| ▸ | NEK1 | Q96PY6 | 5/20 | 0.42 |
| ▸ | AXL | P30530 | 1/20 | 0.42 |
| ▸ | SGK1 | O00141 | 1/20 | 0.42 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.42 |
| ▸ | KIF11 | P52732 | 1/20 | 0.40 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.40 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9907727 | 0.86 | HTR5A (0.50) | HTR5AKIF11KDM4EL3MBTL1HTT | |
| SCHEMBL9909193 | 0.82 | HTR5A (0.58) | HTR5ANEK1AXLKDM4E | |
| SCHEMBL9907702 | 0.79 | HTR5A (0.53) | HTR5AKIF11PARP1DYRK1A | |
| SCHEMBL9909274 | 0.79 | HTR5A (0.47) | HTR5APARP1KDM4EMAPK1L3MBTL1 | |
| SCHEMBL9907758 | 0.79 | HTR5A (0.43) | HTR5AKIF11PARP1KDM4EMAPK1 | |
| SCHEMBL30710238 | 0.78 | MAPK1 (0.46) | NEK1AXLSGK1CAMKK2KIF11 | |
| SCHEMBL9907628 | 0.77 | HTR5A (0.67) | HTR5AKDM4EMAPK1L3MBTL1DYRK1A | |
| SCHEMBL9907765 | 0.77 | HTR5A (0.51) | HTR5APARP1DYRK1A | |
| SCHEMBL9907661 | 0.76 | HTR5A (0.52) | HTR5AKIF11PARP1KDM4EL3MBTL1 | |
| SCHEMBL9907636 | 0.76 | HTR5A (0.64) | HTR5AKIF11PARP1KDM4EL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120142727-A1 | NITROGENOUS-RING ACYLGUANIDINE DERIVATIVE | ASTELLAS PHARMA INC. (JP) | 2012-06-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120142727-A1 | NITROGENOUS-RING ACYLGUANIDINE DERIVATIVE | HTR5A, HTR2A, HTR1E | HTR5A 1/4885NEK1 2164/4885AXL 4425/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.