Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Diethylamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK2 | Q15119 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.35 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.33 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.33 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.32 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.32 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.32 |
| ▸ | RET | P07949 | 1/20 | 0.32 |
| ▸ | MET | P08581 | 1/20 | 0.32 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.32 |
| ▸ | FLT1 | P17948 | 1/20 | 0.32 |
| ▸ | LTK | P29376 | 1/20 | 0.32 |
| ▸ | PRKX | P51817 | 1/20 | 0.32 |
| ▸ | NEK2 | P51955 | 1/20 | 0.32 |
| ▸ | JAK3 | P52333 | 1/20 | 0.32 |
| ▸ | BTK | Q06187 | 1/20 | 0.32 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29540116 | 0.87 | PDK2 (0.47) | PDK2MEN1KMT2AOPRM1OPRD1 | |
| SCHEMBL1307887 | 0.87 | PDK2 (0.47) | PDK2MEN1KMT2AOPRM1OPRD1 | |
| SCHEMBL802764 | 0.82 | PDK2 (0.51) | PDK2MEN1KMT2AOPRM1OPRD1 | |
| SCHEMBL29469448 | 0.82 | PDK2 (0.51) | PDK2MEN1KMT2AOPRM1OPRD1 | |
| SCHEMBL3852074 | 0.81 | ALDH1A1 (0.39) | PDK2MEN1KMT2AOPRM1OPRD1 | |
| SCHEMBL3852176 | 0.81 | PDK2 (0.41) | PDK2MEN1KMT2AOPRM1OPRD1 | |
| SCHEMBL12109715 | 0.81 | PDK2 (0.41) | PDK2MEN1KMT2AOPRM1OPRD1 | |
| SCHEMBL25602287 | 0.81 | PDK2 (0.37) | PDK2MEN1KMT2AOPRM1OPRD1 | |
| SCHEMBL24730435 | 0.80 | MEN1 (0.43) | PDK2MEN1KMT2AOPRM1OPRD1 | |
| SCHEMBL18723342 | 0.78 | ALDH1A1 (0.44) | PDK2MEN1KMT2AOPRM1OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2846374-B1 | Layered structure | SUMITOMO CHEMICAL CO (JP) | 2019-11-06 | — | — | EP | disclosed |
| EP-2846374-A1 | Layered structure | Sumitomo Chemical Company Limited (JP) | 2015-03-11 | — | — | EP | disclosed |
| US-8951646-B2 | Layered structure comprising a layer containing a conjugated polymer compound | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2015-02-10 | — | — | US | disclosed |
| US-20110006294-A1 | LAYERED STRUCTURE | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2011-01-13 | — | — | US | disclosed |
| EP-2249411-A1 | LAYERED STRUCTURE | Sumitomo Chemical Company, Limited (JP) | 2010-11-10 | — | — | EP | disclosed |