⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28044404 | 0.76 | — | — | |
| SCHEMBL1644060 | 0.76 | — | — | |
| SCHEMBL2391208 | 0.70 | — | — | |
| SCHEMBL2393057 | 0.70 | MAPT (0.37) | — | |
| SCHEMBL2388770 | 0.70 | — | — | |
| SCHEMBL24112705 | 0.69 | — | — | |
| SCHEMBL4324488 | 0.69 | ARG1 (0.33) | — | |
| SCHEMBL2388791 | 0.69 | MAPT (0.32) | — | |
| SCHEMBL4760665 | 0.69 | ARG1 (0.33) | — | |
| SCHEMBL13144672 | 0.69 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120283221-A1 | NOVEL PHOSPHONIC ACID COMPOUNDS AS INHIBITORS OF SERINE PROTEASES | GRECO MICHAEL N (US) | 2012-11-08 | — | — | US | disclosed |
| US-8304430-B2 | Phosphonic acid compounds as inhibitors of serine proteases | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2012-11-06 | — | — | US | disclosed |
| EP-1620446-B1 | PIPERAZINE CONTAINING PHOSPHONIC ACID COMPOUNDS AS INHIBITORS OF SERINE PROTEASES | ORTHO MCNEIL PHARMACEUTICAL CORP (US) | 2012-10-24 | — | — | EP | disclosed |
| US-20120238528-A1 | NOVEL PHOSPHONIC ACID COMPOUNDS AS INHIBITORS OF SERINE PROTEASES | GRECO MICHAEL N (US) | 2012-09-20 | — | — | US | disclosed |
| US-8247599-B2 | Phosphonic acid compounds as inhibitors of serine proteases | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2012-08-21 | — | — | US | disclosed |
| US-8212039-B2 | Phosphonic acid compounds as inhibitors of serine proteases | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2012-07-03 | — | — | US | disclosed |
| US-8198440-B2 | Phosphonic acid compounds as inhibitors of serine proteases | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2012-06-12 | — | — | US | disclosed |
| US-8178673-B2 | Phosphonic acid compounds as inhibitors of serine proteases | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2012-05-15 | — | — | US | disclosed |
| US-20110319363-A1 | NOVEL PHOSPHONIC ACID COMPOUNDS AS INHIBITORS OF SERINE PROTEASES | GRECO MICHAEL N (US) | 2011-12-29 | — | — | US | disclosed |
| US-20110092457-A1 | NOVEL PHOSPHONIC ACID COMPOUNDS AS INHIBITORS OF SERINE PROTEASES | GRECO MICHAEL N | 2011-04-21 | — | — | US | disclosed |
| US-20110086819-A1 | NOVEL PHOSPHONIC ACID COMPOUNDS AS INHIBITORS OF SERINE PROTEASES | GRECO MICHAEL N | 2011-04-14 | — | — | US | disclosed |
| US-20090143336-A1 | Novel phosphonic acid compounds as inhibitors of serine proteases | GRECO MICHAEL N | 2009-06-04 | — | — | US | disclosed |
| US-20090137528-A1 | Novel phosphonic acid compounds as inhibitors of serine proteases | GRECO MICHAEL N | 2009-05-28 | — | — | US | disclosed |
| US-20090131371-A1 | Novel phosphonic acid compounds as inhibitors of serine proteases | GRECO MICHAEL N | 2009-05-21 | — | — | US | disclosed |
| US-20090131671-A1 | Novel phosphonic acid compounds as inhibitors of serine proteases | GRECO MICHAEL N | 2009-05-21 | — | — | US | disclosed |
| US-20090124581-A1 | Novel phosphonic acid compounds as inhibitors of serine proteases | GRECO MICHAEL N | 2009-05-14 | — | — | US | disclosed |
| US-20090118508-A1 | Novel phosphonic acid compounds as inhibitors of serine proteases | GRECO MICHAEL N | 2009-05-07 | — | — | US | disclosed |
| US-20090118235-A1 | Novel phosphonic acid compounds as inhibitors of serine proteases | GRECO MICHAEL N | 2009-05-07 | — | — | US | disclosed |
| US-20090118504-A1 | Novel phosphonic acid compounds as inhibitors of serine proteases | GRECO MICHAEL N | 2009-05-07 | — | — | US | disclosed |
| US-7459461-B2 | Phosphonic acid compounds as inhibitors of serine proteases | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2008-12-02 | — | — | US | disclosed |