Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.41 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.40 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | ICMT | O60725 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9909832 | 0.87 | CARM1 (0.39) | MAOBMAOA | |
| SCHEMBL10725887 | 0.77 | KDM4E (0.47) | PARP10AKR1C3AKR1C2KDM4EMEN1 | |
| SCHEMBL13110336 | 0.73 | NQO1 (0.52) | PARP10KDM4EMEN1KMT2AALDH1A1 | |
| SCHEMBL3718805 | 0.70 | NQO1 (0.48) | KDM4EMEN1KMT2AALDH1A1MAPT | |
| SCHEMBL3718619 | 0.70 | NQO1 (0.48) | AKR1C3AKR1C2KDM4EMEN1KMT2A | |
| SCHEMBL30484250 | 0.70 | NQO1 (0.48) | KDM4EMEN1KMT2AALDH1A1MAPT | |
| SCHEMBL13110333 | 0.69 | FFAR1 (0.58) | POLBNPSR1 | |
| SCHEMBL16955982 | 0.67 | NQO1 (0.48) | KDM4EHIF1AMEN1KMT2AALDH1A1 | |
| SCHEMBL10606335 | 0.67 | NQO1 (0.48) | KDM4EMEN1KMT2AALDH1A1MAPT | |
| SCHEMBL20780554 | 0.67 | KMT2A (0.42) | KDM4EMEN1KMT2APKMALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1548024-B1 | PYRAZOLE DERIVATIVES, MEDICINAL COMPOSITION CONTAINING THE SAME, MEDICINAL USE THEREOF, AND INTERMEDIATE FOR PRODUCTION THEREOF | KISSEI PHARMACEUTICAL (JP) | 2012-06-06 | — | — | EP | disclosed |