Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | BCAT1 | P54687 | 2/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.39 |
| ▸ | CDK8 | P49336 | 1/20 | 0.39 |
| ▸ | NEK2 | P51955 | 1/20 | 0.39 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.39 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.39 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23320374 | 0.82 | CHEK1 (0.58) | MAPTKDM4EALDH1A1MAPK1HPGD | |
| SCHEMBL29028696 | 0.79 | CSNK2A1 (0.40) | MAPTKDM4EALDH1A1MAPK1HPGD | |
| SCHEMBL9910895 | 0.77 | ESR2 (0.50) | MAPTKDM4EALDH1A1TDP1CHEK1 | |
| SCHEMBL23320542 | 0.77 | CA9 (0.49) | MAPTKDM4EALDH1A1MAPK1TDP1 | |
| SCHEMBL5137221 | 0.77 | CHEK1 (0.48) | MAPTKDM4EALDH1A1MAPK1HPGD | |
| SCHEMBL23320472 | 0.77 | NPC1 (0.55) | MAPTKDM4EALDH1A1HPGDCA9 | |
| SCHEMBL27359756 | 0.75 | PDE10A (0.38) | MAPTALDH1A1MAPK1ALOX15CDK5 | |
| SCHEMBL9910899 | 0.73 | CHEK1 (0.70) | MAPTKDM4EALDH1A1MAPK1TDP1 | |
| SCHEMBL9910900 | 0.71 | CHEK1 (0.59) | MAPTKDM4EALDH1A1HPGDTDP1 | |
| SCHEMBL16517104 | 0.70 | EGFR (0.38) | MAPTKDM4EALDH1A1TDP1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8546389-B2 | Viral polymerase inhibitors | BIOTA SCIENTIFIC MANAGEMENT PTY LTD. (AU) | 2013-10-01 | — | — | US | disclosed |
| US-20120142686-A1 | VIRAL POLYMERASE INHIBITORS | BIOTA SCIENTIFIC MANAGEMENT PTY LTD | 2012-06-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120142686-A1 | VIRAL POLYMERASE INHIBITORS | POLR2E, POLM, POLR2H | MAPT 1446/4885KDM4E 4521/4885ALDH1A1 456/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.