Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 1/20 | 0.59 |
| ▸ | AURKA | O14965 | 1/20 | 0.59 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.59 |
| ▸ | CDK8 | P49336 | 1/20 | 0.59 |
| ▸ | NEK2 | P51955 | 1/20 | 0.59 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.59 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.59 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.59 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.59 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | NTRK1 | P04629 | 4/20 | 0.40 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.40 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9910899 | 0.89 | CHEK1 (0.70) | CHEK1AURKACSNK1A1CDK8NEK2 | |
| SCHEMBL9108907 | 0.86 | CDK5 (0.44) | CHEK1AURKACSNK1A1CDK8NEK2 | |
| SCHEMBL29161027 | 0.82 | CHEK1 (0.56) | CHEK1AURKACSNK1A1CDK8NEK2 | |
| SCHEMBL5137221 | 0.78 | CHEK1 (0.48) | CHEK1AURKACSNK1A1CDK8NEK2 | |
| SCHEMBL2721702 | 0.77 | CHEK1 (0.54) | CHEK1AURKACSNK1A1CDK8NEK2 | |
| SCHEMBL23320542 | 0.75 | CA9 (0.49) | CHEK1AURKACSNK1A1CDK8NEK2 | |
| SCHEMBL9910895 | 0.75 | ESR2 (0.50) | CHEK1AURKACSNK1A1CDK8NEK2 | |
| SCHEMBL23320456 | 0.74 | CHEK1 (1.00) | CHEK1AURKACSNK1A1CDK8NEK2 | |
| SCHEMBL16517584 | 0.74 | PDE4A (0.39) | CHEK1AURKACSNK1A1CDK8NEK2 | |
| SCHEMBL17112222 | 0.73 | CHEK1 (0.57) | CHEK1AURKACSNK1A1CDK8NEK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8546389-B2 | Viral polymerase inhibitors | BIOTA SCIENTIFIC MANAGEMENT PTY LTD. (AU) | 2013-10-01 | — | — | US | disclosed |
| US-20120142686-A1 | VIRAL POLYMERASE INHIBITORS | BIOTA SCIENTIFIC MANAGEMENT PTY LTD | 2012-06-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120142686-A1 | VIRAL POLYMERASE INHIBITORS | POLR2E, POLM, POLR2H | CHEK1 3433/4885AURKA 2705/4885CSNK1A1 424/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.