Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.31 |
| ▸ | NAALAD2 | Q9Y3Q0 | 1/20 | 0.30 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.30 |
| ▸ | AR | P10275 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13957176 | 0.81 | KDM4C (0.39) | KDM4CALDH1A1TSHRPOLBAR | |
| SCHEMBL17690435 | 0.81 | KDM4C (0.39) | KDM4CALDH1A1TSHRPOLBMAPT | |
| SCHEMBL1979304 | 0.81 | KDM4C (0.39) | KDM4CALDH1A1TSHRPOLBMAPT | |
| SCHEMBL3883297 | 0.81 | KDM4C (0.39) | KDM4CALDH1A1TSHRPOLB | |
| SCHEMBL13655642 | 0.81 | MAPT (0.43) | KDM4CALDH1A1TSHRPOLBMAPT | |
| SCHEMBL13570702 | 0.78 | POLB (0.31) | POLB | |
| SCHEMBL413295 | 0.78 | KDM4C (0.46) | KDM4CALDH1A1TSHRMEN1KMT2A | |
| SCHEMBL22092481 | 0.76 | GAA (0.35) | ALDH1A1TSHRGAAPOLBMAPT | |
| SCHEMBL13484572 | 0.76 | POLB (0.30) | GAAPOLB | |
| SCHEMBL30811127 | 0.76 | KDM4C (0.36) | KDM4CALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8198458-B2 | Non-nucleoside reverse transcriptase inhibitors | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-06-12 | — | — | US | disclosed |
| WO-2010147776-A1 | SUBSTITUTED -1,3,8-TRIAZASPIRO[4.5]DECANE-2,4-DIONES | MERCK SHARP & DOHME CORP. (US) | 2010-12-23 | — | — | WO | disclosed |