Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 13/20 | 0.95 |
| ▸ | NPC1 | O15118 | 12/20 | 0.95 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.95 |
| ▸ | MEN1 | O00255 | 6/20 | 0.95 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.95 |
| ▸ | HPGD | P15428 | 3/20 | 0.95 |
| ▸ | LMNA | P02545 | 2/20 | 0.95 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.95 |
| ▸ | TP53 | P04637 | 1/20 | 0.95 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.62 |
| ▸ | MLLT1 | Q03111 | 3/20 | 0.61 |
| ▸ | TSHR | P16473 | 1/20 | 0.60 |
| ▸ | MLLT3 | P42568 | 1/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4284108 | 0.97 | NPC1 (1.00) | RAB9ANPC1KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL4291514 | 0.96 | NPC1 (1.00) | RAB9ANPC1KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL4280117 | 0.96 | NPC1 (1.00) | RAB9ANPC1KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL509365 | 0.95 | RAB9A (0.90) | RAB9ANPC1KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL4280110 | 0.89 | RAB9A (0.80) | RAB9ANPC1KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL4287780 | 0.87 | RAB9A (0.77) | RAB9ANPC1KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL4285669 | 0.82 | RAB9A (0.69) | RAB9ANPC1KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL15099496 | 0.82 | KMT2A (0.70) | RAB9ANPC1KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL17933816 | 0.80 | NPC1 (0.95) | RAB9ANPC1KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL9911643 | 0.79 | RAB9A (0.70) | RAB9ANPC1KMT2AMEN1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023109779-A1 | USE OF HETEROCYCLIC COMPOUND IN REDUCING ADVERSE REACTIONS CAUSED BY CHEMOTHERAPEUTIC DRUGS | 清华大学 | 2023-06-22 | — | — | WO | disclosed |
| US-20170172987-A1 | ISOXAZOLE TREATMENTS FOR FRONTOTEMPORAL DEMENTIA | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM | 2017-06-22 | — | — | US | disclosed |
| US-20170172987-A1 | ISOXAZOLE TREATMENTS FOR FRONTOTEMPORAL DEMENTIA | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM | 2017-06-22 | — | — | US | disclosed |
| WO-2015143300-A1 | ISOXAZOLE TREATMENTS FOR FRONTOTEMPORAL DEMENTIA | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2015-09-24 | — | — | WO | disclosed |
| US-20140364467-A1 | CHEMICAL INDUCERS OF NEUROGENESIS | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2014-12-11 | — | — | US | disclosed |
| US-20140364467-A1 | CHEMICAL INDUCERS OF NEUROGENESIS | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2014-12-11 | — | — | US | disclosed |
| US-8778940-B2 | Chemical inducers of neurogenesis | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2014-07-15 | — | — | US | disclosed |
| US-8778940-B2 | Chemical inducers of neurogenesis | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2014-07-15 | — | — | US | disclosed |
| US-20130143885-A1 | CHEMICAL INDUCERS OF NEUROGENESIS | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2013-06-06 | — | — | US | disclosed |
| US-20130143885-A1 | CHEMICAL INDUCERS OF NEUROGENESIS | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2013-06-06 | — | — | US | disclosed |
| US-8193225-B2 | Isoxazole amides, derivatives and methods of chemical induction of neurogenesis | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2012-06-05 | — | — | US | disclosed |
| US-8193225-B2 | Isoxazole amides, derivatives and methods of chemical induction of neurogenesis | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2012-06-05 | — | — | US | disclosed |
| US-20090036451-A1 | Chemical inducers of neurogenesis | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM | 2009-02-05 | — | — | US | disclosed |
| US-20090036451-A1 | Chemical inducers of neurogenesis | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM | 2009-02-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170172987-A1 | ISOXAZOLE TREATMENTS FOR FRONTOTEMPORAL DEMENTIA | GRN, PSEN1, PSEN2 | RAB9A 4377/4885NPC1 1125/4885KMT2A 4640/4885 |
| US-20140364467-A1 | CHEMICAL INDUCERS OF NEUROGENESIS | DCX, NES, GAP43 | RAB9A 2878/4885NPC1 1941/4885KMT2A 1862/4885 |
| US-20090036451-A1 | Chemical inducers of neurogenesis | DCX, NES, GAP43 | RAB9A 2878/4885NPC1 1941/4885KMT2A 1862/4885 |
| US-20130143885-A1 | CHEMICAL INDUCERS OF NEUROGENESIS | DCX, NES, GAP43 | RAB9A 2878/4885NPC1 1941/4885KMT2A 1862/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.