SCHEMBL509365

SCHEMBL509365

O=C(NC1CC1)c1cc(-c2cccs2)on1

nearest known ligand 0.90

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
RAB9A P51151 10/20 0.90
NPC1 O15118 7/20 0.90
MEN1 O00255 7/20 0.90
KMT2A Q03164 7/20 0.90
SMN1; SMN2 Q16637 5/20 0.90
LMNA P02545 4/20 0.90
HPGD P15428 3/20 0.90
ALDH1A1 P00352 3/20 0.90
TP53 P04637 1/20 0.90
POLB P06746 3/20 0.60
MLLT1 Q03111 1/20 0.60
KDM4E B2RXH2 2/20 0.58
NPSR1 Q6W5P4 1/20 0.58
HTT P42858 1/20 0.58
S1PR1 P21453 1/20 0.57
TSHR P16473 2/20 0.57
MAPT P10636 1/20 0.56
TDP1 Q9NUW8 1/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9911599 0.95 RAB9A (0.95) RAB9ANPC1MEN1KMT2ASMN1; SMN2
SCHEMBL4284108 0.95 NPC1 (1.00) RAB9ANPC1MEN1KMT2ASMN1; SMN2
SCHEMBL4280110 0.94 RAB9A (0.80) RAB9ANPC1MEN1KMT2ASMN1; SMN2
SCHEMBL4280117 0.94 NPC1 (1.00) RAB9ANPC1MEN1KMT2ASMN1; SMN2
SCHEMBL4291514 0.94 NPC1 (1.00) RAB9ANPC1MEN1KMT2ASMN1; SMN2
SCHEMBL4287780 0.89 RAB9A (0.77) RAB9ANPC1MEN1KMT2ASMN1; SMN2
SCHEMBL15099496 0.87 KMT2A (0.70) RAB9ANPC1MEN1KMT2ASMN1; SMN2
SCHEMBL4285669 0.87 RAB9A (0.69) RAB9ANPC1MEN1KMT2ASMN1; SMN2
SCHEMBL9911643 0.81 RAB9A (0.70) RAB9ANPC1MEN1KMT2ASMN1; SMN2
SCHEMBL4279011 0.81 RAB9A (0.67) RAB9ANPC1MEN1KMT2ASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 228 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250340837-A1 CELLS UNIVERSITY OF GENEVA (CH) 2025-11-06 US claimed
EP-4615506-A1 USE OF GSK-3 ACTIVATIOR TO MODULATE PROTEASOME ACTIVITY TO PREVENT AGEING ASSOCIATED CONDITIONS AND DISEASES Sahin, Fikret (TR) 2025-09-17 EP claimed
CN-120131648-A HIV-1 latent infection activator, medicine and application 上海市重大传染病和生物安全研究院 2025-06-13 CN claimed
CN-120082502-A Method for differentiating pluripotent stem cells into insulin-secreting cells 广西中医药大学附属瑞康医院(广西中西医结合医院) 2025-06-03 CN claimed
CN-119909067-A Small molecular compound combination and application thereof in glioma treatment 暨南大学 2025-05-02 CN claimed
CN-119752767-A Method for inducing and differentiating human umbilical cord mesenchymal stem cells into islet microsphere organs and application 辽宁医学诊疗科技研发中心有限公司 2025-04-04 CN claimed
CN-119432708-A In vitro induction method of gastric organoids and application thereof 广州国家实验室 2025-02-14 CN claimed
EP-4504916-A1 CELLS University of Geneva (CH) 2025-02-12 EP claimed
WO-2024258363-A1 USE OF GSK-3 ACTIVATIOR TO MODULATE PROTEASOME ACTIVITY TO PREVENT AGEING ASSOCIATED CONDITIONS AND DISEASES SAHIN FIKRET (TR) 2024-12-19 WO claimed
EP-4440585-A1 METHOD OF GENERATING FUNCTIONAL ISLETS FROM PLURIPOTENT STEM CELLS Hangzhou Reprogenix Bioscience, Inc. (CN) 2024-10-09 EP claimed
US-20220362254-A1 METHODS FOR REPROGRAMMING CANCER CELLS UNIV JEFFERSON (US) 2022-11-17 US claimed
WO-2022204377-A1 NOVEL CHEMICAL COMBINATIONS AND METHODS OF USE THEREOF, TOWARDS DIFFERENTIATION OF HUMAN PROGENITOR CELLS INTO FUNCTIONAL β CELLS SALK INSTITUTE FOR BIOLOGICAL STUDIES (US) 2022-09-29 WO claimed
WO-2022077549-A1 COMPOSITION AND METHOD FOR TRANSDIFFERENTIATING NON-NEURONAL CELLS INTO NEURONS 中国科学院动物研究所 2022-04-21 WO claimed
US-20210363491-A1 PRODUCTION OF INSULIN PRODUCING CELLS NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2021-11-25 US claimed
US-11021687-B2 Production of differentiated enteroendocrine cells and insulin producing cells THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) 2021-06-01 US claimed
US-10857185-B2 Compositions and methods for reprogramming non-neuronal cells into neuron-like cells Beihao Stem Cell and Regenerative Medicine Research Institutes Co., Ltd. (CN) 2020-12-08 US claimed
US-20200277567-A1 METHODS FOR CHEMICALLY INDUCED LINEAGE REPROGRAMMING BEIHAO STEM CELL AND REGENERATIVE MEDICINE RESEARCH INSTITUTE CO., LTD. (CN) 2020-09-03 US claimed
US-20180273906-A1 MICROVESICLE AND STEM CELL COMPOSITIONS FOR THERAPEUTIC APPLICATIONS IPS HEART 2018-09-27 US claimed
US-20180193386-A1 Compositions and Methods For Reprograming Non-Neuronal Cells Into Neuron-Like Cells BEIHAO STEM CELL AND REGENERATIVE MEDICINE RESEARCH INSTITUTE CO., LTD. (CN) 2018-07-12 US claimed
US-20170349884-A1 Production of Differentiated Enteroendocrine Cells and Insulin Producing Cells THE BRIGHAM AND WOMEN'S HOSPITAL, INC. 2017-12-07 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180273906-A1 MICROVESICLE AND STEM CELL COMPOSITIONS FOR THERAPEUTIC APPLICATIONS EXOSC9, EXOSC5, EXOSC4 RAB9A 334/4885NPC1 1167/4885MEN1 2441/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.