Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.42 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | FOLH1 | Q04609 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.31 |
| ▸ | CPT2 | P23786 | 1/20 | 0.31 |
| ▸ | ACLY | P53396 | 1/20 | 0.31 |
| ▸ | TET2 | Q6N021 | 3/20 | 0.31 |
| ▸ | KDM4A | O75164 | 2/20 | 0.31 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.31 |
| ▸ | KDM2A | Q9Y2K7 | 2/20 | 0.31 |
| ▸ | TET3 | O43151 | 1/20 | 0.31 |
| ▸ | CACNA2D1 | P54289 | 2/20 | 0.30 |
| ▸ | CACNB3 | P54284 | 1/20 | 0.30 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.30 |
| ▸ | PGR | P06401 | 1/20 | 0.30 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Formic Acid SCHEMBL20836208 | 0.77 | TDP1 (0.78) | TDP1SMN1; SMN2SLC22A6GABRR1LMNA | |
| SCHEMBL9213672 | 0.76 | TDP1 (0.59) | TDP1SMN1; SMN2SLC22A6GABRR1LMNA | |
| SCHEMBL22151 | 0.76 | TDP1 (1.00) | TDP1SMN1; SMN2SLC22A6GABRR1LMNA | |
| SCHEMBL165643 | 0.76 | TDP1 (1.00) | TDP1SMN1; SMN2SLC22A6GABRR1LMNA | |
| SCHEMBL17517216 | 0.76 | TDP1 (1.00) | TDP1SMN1; SMN2SLC22A6GABRR1LMNA | |
| SCHEMBL16925719 | 0.76 | TDP1 (1.00) | TDP1SMN1; SMN2SLC22A6GABRR1LMNA | |
| SCHEMBL9478562 | 0.75 | SLC22A6 (0.46) | TDP1SMN1; SMN2SLC22A6GABRR1LMNA | |
| SCHEMBL8389178 | 0.74 | TDP1 (0.56) | TDP1SMN1; SMN2SLC22A6FOLH1CACNA2D1 | |
| SCHEMBL705775 | 0.74 | TDP1 (0.56) | TDP1SMN1; SMN2SLC22A6GABRR1LMNA | |
| SCHEMBL27510549 | 0.74 | TDP1 (0.72) | TDP1SMN1; SMN2SLC22A6GABRR1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8952061-B2 | Methods and compounds regulating the erythroid response to iron deficiency | UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) | 2015-02-10 | — | — | US | disclosed |
| US-20130072428-A1 | Methods and Compounds Regulating the Erythroid Response to Iron Deficiency | UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) | 2013-03-21 | — | — | US | disclosed |
| US-20120142590-A1 | Methods and Compounds Regulating the Erythroid Response to Iron Deficiency | UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) | 2012-06-07 | — | — | US | disclosed |
| US-20100184643-A1 | Methods and Compounds Regulating the Erythroid Response to Iron Deficiency | UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) | 2010-07-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120142590-A1 | Methods and Compounds Regulating the Erythroid Response to Iron Deficiency | MCL1, FECH, MPL | TDP1 4776/4885SMN1; SMN2 4522/4885SLC22A6 2599/4885 |
| US-20130072428-A1 | Methods and Compounds Regulating the Erythroid Response to Iron Deficiency | HIF1AN, IDH2, IDH3B | TDP1 4822/4885SMN1; SMN2 4453/4885SLC22A6 1966/4885 |
| US-20100184643-A1 | Methods and Compounds Regulating the Erythroid Response to Iron Deficiency | EPOR, MPL, MCL1 | TDP1 4797/4885SMN1; SMN2 4488/4885SLC22A6 2478/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.