Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.74 |
| ▸ | TSHR | P16473 | 2/20 | 0.64 |
| ▸ | LTA4H | P09960 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.55 |
| ▸ | HTT | P42858 | 2/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | CACNA1F | O60840 | 2/20 | 0.54 |
| ▸ | CACNA1D | Q01668 | 2/20 | 0.54 |
| ▸ | CACNA1S | Q13698 | 2/20 | 0.54 |
| ▸ | CACNA1C | Q13936 | 2/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12726118 | 0.98 | SMN1; SMN2 (0.71) | SMN1; SMN2TSHRLTA4HALDH1A1MEN1 | |
| SCHEMBL13861966 | 0.90 | SMN1; SMN2 (0.67) | SMN1; SMN2TSHRLTA4HALDH1A1MEN1 | |
| SCHEMBL12409045 | 0.85 | SMN1; SMN2 (0.74) | SMN1; SMN2LTA4HALDH1A1MEN1LMNA | |
| SCHEMBL2329109 | 0.84 | ALDH1A1 (0.67) | SMN1; SMN2TSHRLTA4HALDH1A1MEN1 | |
| SCHEMBL763134 | 0.84 | SMN1; SMN2 (0.71) | SMN1; SMN2TSHRLTA4HALDH1A1MEN1 | |
| SCHEMBL8351425 | 0.84 | SMN1; SMN2 (0.71) | SMN1; SMN2TSHRLTA4HALDH1A1MEN1 | |
| SCHEMBL14453571 | 0.83 | SMN1; SMN2 (0.97) | SMN1; SMN2TSHRALDH1A1MEN1KMT2A | |
| SCHEMBL18010724 | 0.82 | SMN1; SMN2 (0.74) | SMN1; SMN2TSHRLTA4HALDH1A1MEN1 | |
| SCHEMBL14233388 | 0.82 | TSHR (0.64) | SMN1; SMN2TSHRLTA4HALDH1A1KDM4E | |
| SCHEMBL10268381 | 0.81 | LTA4H (0.70) | SMN1; SMN2TSHRLTA4HALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8198458-B2 | Non-nucleoside reverse transcriptase inhibitors | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-06-12 | — | — | US | disclosed |
| US-7517998-B2 | Benzothiazole or benzothiazine derivative of dipyrido(2,3;b:2',3'-e) diazepin-6-one; viricide against human t-cell leukemia/lymphoma virus | BOEHRINGER INGELHEIM INTERNATIONAL GMBH | 2009-04-14 | — | — | US | disclosed |