Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.72 |
| ▸ | MEN1 | O00255 | 5/20 | 0.72 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.72 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.72 |
| ▸ | POLB | P06746 | 3/20 | 0.72 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 2/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | GALR3 | O60755 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL737722 | 0.85 | MAPT (1.00) | MAPTMEN1KMT2ATDP1POLB | |
| SCHEMBL29409289 | 0.85 | MAPT (1.00) | MAPTMEN1KMT2ATDP1POLB | |
| SCHEMBL17736221 | 0.81 | TDP1 (0.60) | MAPTMEN1KMT2ATDP1POLB | |
| Hydrochloric Acid SCHEMBL3973011 | 0.81 | MAPT (0.92) | MAPTMEN1KMT2ATDP1POLB | |
| Hydrochloric Acid SCHEMBL3973012 | 0.81 | MAPT (0.92) | MAPTMEN1KMT2ATDP1POLB | |
| SCHEMBL8601406 | 0.79 | MAPT (0.88) | MAPTMEN1KMT2ATDP1POLB | |
| SCHEMBL31094848 | 0.79 | MAPT (0.57) | MAPTMEN1KMT2ATDP1POLB | |
| SCHEMBL5817998 | 0.79 | TDP1 (0.57) | MAPTMEN1KMT2ATDP1POLB | |
| SCHEMBL10714493 | 0.78 | TDP1 (0.85) | MAPTMEN1KMT2ATDP1POLB | |
| SCHEMBL3178960 | 0.78 | MAPT (0.85) | MAPTMEN1KMT2ATDP1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012075381-A1 | SUBSTITUTED PURINE AND 7 - DEAZAPURINE COMPOUNDS AS MODULATORS OF EPIGENETIC ENZYMES | Epizyme, Inc. (US) | 2012-06-07 | — | — | WO | disclosed |