Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 1/20 | 0.38 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.38 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.38 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.38 |
| ▸ | P2RX2 | Q9UBL9 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.37 |
| ▸ | NISCH | Q9Y2I1 | 2/20 | 0.37 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.37 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.37 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.34 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9282206 | 1.00 | PDE3B (0.38) | PDE3BPDE3APDE10AP2RX3P2RX2 | |
| SCHEMBL22871103 | 0.82 | ADRA2A (0.44) | PDE3BPDE3APDE10AP2RX3P2RX2 | |
| SCHEMBL15077043 | 0.79 | PDE4A (0.42) | PDE3BPDE3APDE10ANISCHADRA2A | |
| SCHEMBL24498230 | 0.77 | NISCH (0.40) | PDE3BPDE3APDE10AP2RX3P2RX2 | |
| SCHEMBL17972910 | 0.77 | CARM1 (0.43) | PDE3BPDE3APDE10ANISCHADRA2A | |
| SCHEMBL22426537 | 0.77 | CARM1 (0.43) | PDE3BPDE3APDE10ANISCHADRA2A | |
| SCHEMBL24498617 | 0.77 | MCHR1 (0.48) | PDE3BPDE3APDE10AP2RX3P2RX2 | |
| SCHEMBL10267024 | 0.75 | HRH1 (0.57) | SLC6A2SLC6A3SLC6A4NISCHADRA2A | |
| SCHEMBL798745 | 0.75 | KAT2B (0.52) | PDE3BPDE3APDE10AP2RX3NISCH | |
| SCHEMBL3126948 | 0.75 | HTR1A (0.43) | PDE3BPDE3APDE10AP2RX3P2RX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012072512-A1 | N-CYCLOBUTYL-IMIDAZOPYRIDINE OR -PYRAZOLOPYRIDINE CARBOXAMIDES AS TRPV1 ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2012-06-07 | — | — | WO | disclosed |