Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 2/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.38 |
| ▸ | CTNNB1 | P35222 | 4/20 | 0.35 |
| ▸ | WNT3A | P56704 | 4/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.35 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.34 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | CTSK | P43235 | 3/20 | 0.33 |
| ▸ | CTSS | P25774 | 1/20 | 0.33 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.33 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.33 |
| ▸ | MAOA | P21397 | 2/20 | 0.32 |
| ▸ | MAOB | P27338 | 1/20 | 0.32 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.32 |
| ▸ | PPARG | P37231 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9913545 | 0.85 | KDM4A (0.40) | SLC6A2SLC6A4SLC6A3CTNNB1WNT3A | |
| SCHEMBL3180280 | 0.80 | SLC6A2 (0.52) | SLC6A2SLC6A4SLC6A3CTNNB1WNT3A | |
| SCHEMBL13539191 | 0.75 | KDM4A (0.43) | SLC6A2SLC6A4SLC6A3PTGS2NOTUM | |
| SCHEMBL4280275 | 0.67 | SLC6A2 (0.46) | SLC6A2SLC6A4SLC6A3CTNNB1WNT3A | |
| SCHEMBL13539118 | 0.67 | SLC6A4 (0.53) | SLC6A2SLC6A4SLC6A3CTNNB1WNT3A | |
| SCHEMBL14495182 | 0.66 | SLC6A2 (0.52) | SLC6A2SLC6A4SLC6A3CTNNB1WNT3A | |
| SCHEMBL8871162 | 0.65 | SLC6A2 (0.55) | SLC6A2SLC6A4SLC6A3CTNNB1WNT3A | |
| SCHEMBL27811484 | 0.64 | SLC6A2 (0.43) | SLC6A2SLC6A4SLC6A3CTNNB1WNT3A | |
| SCHEMBL12427121 | 0.64 | SLC6A2 (0.68) | SLC6A2SLC6A4SLC6A3PTGS2EPHX2 | |
| SCHEMBL2307317 | 0.63 | SLC6A2 (0.53) | SLC6A2SLC6A4SLC6A3CTNNB1WNT3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8198274-B2 | Substituted indolyl and indazolyl derivatives and uses thereof | ROCHE PALO ALTO LLC (US) | 2012-06-12 | — | — | US | disclosed |
| US-20100016312-A1 | Substituted indolyl and indazolyl derivatives and uses thereof | ROCHE PALO ALTO LLC | 2010-01-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100016312-A1 | Substituted indolyl and indazolyl derivatives and uses thereof | MAOB, MAOA, TPH1 | SLC6A2 8/4885SLC6A4 4/4885SLC6A3 7/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.